Evidence map›Paper›PMID 39941117›Full record

ArticleInternational journal of molecular sciences2025

Histology of the Upper Gastrointestinal Tract, Morphometry and Lymphocyte Subpopulations of the Duodenal Mucosa: Insights from Healthy Individuals.

Albert Martín-Cardona, Anna Carrasco, Carme Ferrer, Clarisa González-Mínguez, Luis Luizaga-Velasco, Xavier Tarroch, Gerardo Gonzalez-Puglia, Eva Tristán, Natalia Berenice Cardozo-Rembado, Natàlia Pallarès and 16 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Albert Martín-CardonaDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.ORCID 0000-0002-7090-0106
Anna CarrascoDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.
Carme FerrerPathology Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.
Clarisa González-MínguezPathology Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.
Luis Luizaga-VelascoPathology Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.
Xavier TarrochPathology Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.ORCID 0000-0002-7673-5818
Gerardo Gonzalez-PugliaDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.ORCID 0009-0002-7811-2232
Eva TristánDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.ORCID 0000-0002-9317-2447
Natalia Berenice Cardozo-RembadoDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.ORCID 0009-0006-5018-708X
Natàlia PallarèsBiostatistics Support and Research Unit, Germans Trias I Pujol Research Institute and Hospital (IGTP), 08916 Badalona, Catalonia, Spain.ORCID 0000-0002-1462-379X
Cristian TebéBiostatistics Support and Research Unit, Germans Trias I Pujol Research Institute and Hospital (IGTP), 08916 Badalona, Catalonia, Spain.
Beatriz ArauDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.
Isabel SalvadorDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.
Ingrid FajardoDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.
Raimon RifàDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.ORCID 0000-0003-1911-3681
Laura RuizDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.
Pablo Ruiz-RamírezDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.
Sònia Fernández-HerreraDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.ORCID 0009-0000-2096-1712
Agnès RagaDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.
Montserrat AceitunoDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.ORCID 0000-0003-0352-9527
Yamile ZabanaDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.
Carme LorasDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.
Mireia FonolledaDepartment of Immunology, Catlab, 08232 Viladecavalls, Catalonia, Spain.
Jordi RoigéDepartment of Genetics, Catlab, 08232 Viladecavalls, Catalonia, Spain.
Fernando Fernández-BañaresDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.ORCID 0000-0002-1489-504X
Maria EsteveDigestive Diseases Department, Hospital Universitari Mútua Terrassa, University of Barcelona, 08221 Terrassa, Catalonia, Spain.ORCID 0000-0001-7716-0027

Funding

Department of Health of Catalonia: Program for the Incorporation of Support Staff into Research Groups SLT028/23/000194Fundació Docència i Recerca Mútua Terrassa BE0163Societat Catalana de Digestologia Iniciació a la recerca
6 · The paper itself

Abstract

The upper oesophagogastrointestinal (UEGI) tract histology, intestinal morphometry and lymphocyte subpopulations of healthy people is scarcely known. In research studies of inflammation involving the UEGI tract, there is a lack of adequate healthy controls. Aims: To evaluate the histology of the UEGI tract and the duodenal lymphocyte subpopulations of healthy volunteers and patients with gastroesophageal reflux disease (GERD), the latter to assess if it could replace healthy subjects. Healthy individuals were excluded if they had symptoms, comorbidities, pregnancy, toxics, medications or abnormal blood analysis. Subjects in both groups with abnormal duodenal intraepithelial lymphocyte (IEL) counts were also excluded. A total of 280 subjects were assessed, and 37 were included (23 healthy and 14 with GERD). The GERD group showed a higher IEL count (median [IQR]: 19.5 [17-22]), than healthy group: (15 [12-18]),

Indexed as

DuodenumGastroesophageal RefluxIntestinal MucosaLymphocyte SubsetsUpper Gastrointestinal TractAdultCase-Control StudiesFemaleHealthy VolunteersHumansMaleMiddle Agedeosinophilsflow cytometryhealthy mucosainnate lymphoid cellsintestinal morphometryintraepithelial lymphocytesmast cellsnatural killer cellsγδ+ cells

Identifiers

PMID39941117
PMCPMC11818500

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.