Evidence map›Paper›PMID 39941036›Full record

ArticleInternational journal of molecular sciences2025

2-{

Winnie Deuther-Conrad, Dirk Schepmann, Isabel Iriepa, Francisco López-Muñoz, Mourad Chioua, Bernhard Wünsch, Abdelouahid Samadi, José Marco-Contelles

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Winnie Deuther-ConradHelmholtz-Zentrum Dresden-Rossendorf (HZDR), Department of Neuroradiopharmaceuticals, Institute of Radiopharmaceutical Cancer Research, D-04318 Leipzig, Germany.ORCID 0000-0003-3168-3062
Dirk SchepmannInstitut für Pharmazeutische und Medizinische Chemie, Universität Münster, Corrensstraße 48, D-48149 Münster, Germany.
Isabel IriepaDepartamento de Química Orgánica y Química Inorgánica, Instituto de Investigación Química "Andrés M. del Río" (IQAR), Universidad de Alcalá, Alcalá de Henares, 28805 Madrid, Spain.ORCID 0000-0003-3475-9624
Francisco López-MuñozFaculty of Health Sciences-HM Hospitals, University Camilo José Cela, 28692 Madrid, Spain.ORCID 0000-0002-5188-6038
Mourad ChiouaInstitute of General Organic Chemistry (CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain.
Bernhard WünschInstitut für Pharmazeutische und Medizinische Chemie, Universität Münster, Corrensstraße 48, D-48149 Münster, Germany.ORCID 0000-0002-9030-8417
Abdelouahid SamadiDepartment of Chemistry, College of Science, United Arab Emirates University, Al Ain 15551, United Arab Emirates.ORCID 0000-0003-1766-4471
José Marco-ContellesInstitute of General Organic Chemistry (CSIC), C/Juan de la Cierva 3, 28006 Madrid, Spain.

Funding

Spanish State Research Agency 10.13039/501100011033
6 · The paper itself

Abstract

Sigma receptors (σRs) represent very attractive biological targets for the development of potential agents for the treatment of several neurological disorders. In the search for new small molecule drugs against neuropathic pain, we identified 2-{[2-(1-benzylpiperidin-4-yl)ethyl]amino}-6-[methyl(prop-2-yn-1-yl)amino]pyridine-3,5-dicarbonitrile (

Indexed as

NitrilesPiperidinesPyridinesReceptors, sigmaAcetylcholinesteraseAnimalsButyrylcholinesteraseCholinesterase InhibitorsHumansMolecular Docking SimulationProtein BindingSigma-1 ReceptorAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsNitrilesPiperidinesPyridinesReceptors, sigmaSigma-1 Receptorsigma-2 receptorADMEcomputational chemistrydockingmultifunctional pyridinessigma receptors

Identifiers

PMID39941036
PMCPMC11818082

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.