Evidence map›Paper›PMID 39940970›Full record

ArticleInternational journal of molecular sciences2025

Hemostatic Profile and Serum Levels of Interferon Gamma-Induced Protein 10 (IP-10) in Neonates Born to Mothers with COVID-19 During the Peripartum Period.

Rozeta Sokou, Efstathia-Danai Bikouli, Andreas G Tsantes, Panagiotis Halvatsiotis, Dimitra Houhoula, Paschalia Taliaka Kopanou, Paraskevi Liakou, Evangelia-Filothei Tavoulari, Daniele Piovani, Stefanos Bonovas and 5 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rozeta SokouNeonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0002-9972-8901
Efstathia-Danai BikouliNeonatal Intensive Care Unit, "Agios Panteleimon" General Hospital of Nikea, 18454 Piraeus, Greece.ORCID 0000-0002-6129-7616
Andreas G TsantesMicrobiology Department, "Saint Savvas" Oncology Hospital, 11522 Athens, Greece.ORCID 0000-0002-3695-0759
Panagiotis HalvatsiotisSecond Department of Internal Medicine, Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0001-8559-8977
Dimitra HouhoulaDepartment of Food Science and Technology, University of West Attica, 12243 Athens, Greece.ORCID 0000-0002-4692-2081
Paschalia Taliaka KopanouNeonatal Intensive Care Unit, "Agios Panteleimon" General Hospital of Nikea, 18454 Piraeus, Greece.ORCID 0000-0002-4978-2539
Paraskevi LiakouNeonatal Intensive Care Unit, "Agios Panteleimon" General Hospital of Nikea, 18454 Piraeus, Greece.ORCID 0000-0002-0739-1484
Evangelia-Filothei TavoulariNeonatal Intensive Care Unit, "Agios Panteleimon" General Hospital of Nikea, 18454 Piraeus, Greece.
Daniele PiovaniDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, Italy.ORCID 0000-0002-1414-6639
Stefanos BonovasDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20090 Milan, Italy.ORCID 0000-0001-6102-6579
Zoi IliodromitiNeonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0003-4316-7305
Theodora BoutsikouNeonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Nicoletta IacovidouNeonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.ORCID 0000-0001-8021-6191
Martha TheodorakiNeonatal Intensive Care Unit, "Agios Panteleimon" General Hospital of Nikea, 18454 Piraeus, Greece.
Argirios E TsantesBlood Bank Unit, Laboratory of Haematology, "Attiko" Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic has raised significant concerns regarding its potential impact on maternal and neonatal health. This study aimed to investigate the immunologic and hemostatic profiles of neonates exposed to SARS-CoV-2 during the peripartum period (0-14 days prior to delivery). This retrospective study included 28 neonates born to COVID-19-positive mothers during the peripartum period and a control group of 54 neonates born to mothers who never tested positive for SARS-CoV-2 during pregnancy. Arterial blood samples were collected from all neonates on the second day of life for the simultaneous assessment of full blood count, C-reactive protein (CRP), serum interleukin-6 (IL-6), and Interferon gamma-induced protein 10 (IP-10) levels, as well as Rotational Thromboelastometry (ROTEM) tests (EXTEM, INTEM, and NATEM). Neonates born to COVID-19-positive mothers and those born to COVID-19-negative mothers exhibited similar coagulation profiles based on ROTEM analysis. Multiple linear regression analysis revealed that peripartum COVID-19 infection was associated with higher IP-10 levels in neonates (coefficient: +16.8, 95% CI: +9.0 to +24.6,

Indexed as

Chemokine CXCL10COVID-19HemostasisInfectious Disease Transmission, VerticalPregnancy Complications, InfectiousFemaleHumansIncidenceInfant, NewbornInterferon-gammaMalePeripartum PeriodPregnancyRetrospective StudiesSARS-CoV-2ThrombelastographyChemokine CXCL10CXCL10 protein, humanInterferon-gammamaternal COVID-19neonatal hemostasisneonatal immunologic profileperinatal SARS-CoV-2 exposurethromboelastometry parameters

Identifiers

PMID39940970
PMCPMC11818117

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.