Evidence map›Paper›PMID 39940963›Full record

ArticleInternational journal of molecular sciences2025

Multidrug Resistance-Associated Proteins 3 and 5 Play a Role in the Hepatic Transport of Mercuric Conjugates of Glutathione.

Maria Eduarda Andrade Galiciolli, Lucy Joshee, Cláudia S Oliveira, Jennifer L Barkin, Christy C Bridges

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria Eduarda Andrade GaliciolliDepartment of Biomedical Sciences, Mercer University School of Medicine, Macon, GA 31207, USA.ORCID 0000-0003-0032-9976
Lucy JosheeDepartment of Biomedical Sciences, Mercer University School of Medicine, Macon, GA 31207, USA.
Cláudia S OliveiraInstituto de Pesquisa Pelé Pequeno Príncipe, Curitiba 80250-060, PR, Brazil.ORCID 0000-0002-2004-5316
Jennifer L BarkinDepartment of Community Medicine, Mercer University School of Medicine, Macon, GA 31207, USA.
Christy C BridgesDepartment of Biomedical Sciences, Mercer University School of Medicine, Macon, GA 31207, USA.ORCID 0000-0003-1603-1445

Funding

Uptake of Mercury at the Basolateral Membrane of Isolated Proximal TubulesR15ES030867 · NIEHS · MERCER UNIVERSITY MACON · PI BRIDGES, CHRISTY C · 2020 to 2020
$425k
NIEHS NIH HHS R15 ES030867NIH HHS 1R15ES030867-24A1
6 · The paper itself

Abstract

Multidrug resistance proteins (MRPs) are transporters for metabolic waste and xenobiotics and are known to export a wide range of substances from renal tubular cells. This study aimed to define and characterize the transport of mercuric conjugates of glutathione (GSH-Hg-GSH) in inside-out membrane vesicles containing MRP3 and MPR5. The functionality of the MRP3 and MRP5 vesicles was confirmed by measuring the uptake of [

Indexed as

ATP-Binding Cassette, Sub-Family C ProteinsGlutathioneLiverMercuryAnimalsBiological TransportHumansKineticsRatsATP-Binding Cassette, Sub-Family C ProteinsGlutathioneMercurymultidrug resistance-associated protein 3heavy metalslivermercurymultidrug resistance-associated transportertransport

Identifiers

PMID39940963
PMCPMC11818351

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.