Evidence map›Paper›PMID 39940918›Full record

ArticleInternational journal of molecular sciences2025

CDK6-Dependent, CDK4-Independent Synovial Hyperplasia in Arthritic Mice and Tumor Necrosis Factor-α-Induced Proliferation of Synovial Fibroblasts.

Rie Komatsu, Ryoji Fujii, Toru Ogasawara, Yuki Suzuki-Takahashi, Sandy Chen, Yodo Sugishita, Hisateru Niki, Kazuo Yudoh

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rie KomatsuInstitute of Medical Science, St. Marianna University School of Medicine, Kawasaki 216-8512, Kanagawa, Japan.ORCID 0009-0009-2533-0376
Ryoji FujiiInstitute of Medical Science, St. Marianna University School of Medicine, Kawasaki 216-8512, Kanagawa, Japan.ORCID 0009-0001-7703-591X
Toru OgasawaraDepartment of Oral and Maxillofacial Surgery, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.ORCID 0000-0002-2996-081X
Yuki Suzuki-TakahashiInstitute of Medical Science, St. Marianna University School of Medicine, Kawasaki 216-8512, Kanagawa, Japan.
Sandy ChenInstitute of Medical Science, St. Marianna University School of Medicine, Kawasaki 216-8512, Kanagawa, Japan.
Yodo SugishitaInstitute of Medical Science, St. Marianna University School of Medicine, Kawasaki 216-8512, Kanagawa, Japan.
Hisateru NikiDepartment of Orthopedic Surgery, St. Marianna University School of Medicine, Kawasaki 216-8511, Kanagawa, Japan.ORCID 0000-0002-2893-6367
Kazuo YudohInstitute of Medical Science, St. Marianna University School of Medicine, Kawasaki 216-8512, Kanagawa, Japan.

Funding

Japan Society for the Promotion of Science JP21K09335, JP21K09286, JP24K12427
6 · The paper itself

Abstract

Palbociclib, a dual CDK4/6 kinase inhibitor used for breast cancer, has been explored as a treatment option for rheumatoid arthritis (RA). Preclinical studies have reported palbociclib-induced myelosuppression, but no such effects have been observed in

Indexed as

Arthritis, ExperimentalArthritis, RheumatoidCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6FibroblastsSynovial MembraneTumor Necrosis Factor-alphaAnimalsCell ProliferationHyperplasiaMaleMiceMice, KnockoutCdk4 protein, mouseCdk6 protein, mouseCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Tumor Necrosis Factor-alphaCDK4CDK6collagen-induced arthritisG1 phase progressionsynovial hyperplasia

Identifiers

PMID39940918
PMCPMC11817658

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.