Unraveling the Role of RSPRY1 in TGF-β Pathway Dysregulation: Insights into the Pathogenesis of Spondyloepimetaphyseal Dysplasia.

Gozde Imren, Beren Karaosmanoglu, Bihter Muratoglu, Cansu Ozdemir, Gulen Eda Utine, Pelin Ozlem Simsek-Kiper, Ekim Z Taskiran

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gozde ImrenDepartment of Medical Genetics, Faculty of Medicine, Hacettepe University, 06100 Ankara, Türkiye.ORCID 0000-0002-2556-0421

Beren KaraosmanogluDepartment of Medical Genetics, Faculty of Medicine, Hacettepe University, 06100 Ankara, Türkiye.ORCID 0000-0001-5564-4813

Bihter MuratogluDepartment of Stem Cell Sciences, Institute of Health Sciences, Hacettepe University, 06100 Ankara, Türkiye.ORCID 0009-0001-2501-1668

Cansu OzdemirDepartment of Stem Cell Sciences, Institute of Health Sciences, Hacettepe University, 06100 Ankara, Türkiye.

Gulen Eda UtineDepartment of Pediatric Genetics, Faculty of Medicine, Hacettepe University, 06100 Ankara, Türkiye.

Pelin Ozlem Simsek-KiperDepartment of Pediatric Genetics, Faculty of Medicine, Hacettepe University, 06100 Ankara, Türkiye.

Ekim Z TaskiranDepartment of Medical Genetics, Faculty of Medicine, Hacettepe University, 06100 Ankara, Türkiye.ORCID 0000-0001-6040-6625

Funding

Hacettepe University TSA-2021-19468

6 · The paper itself

Abstract

Skeletal dysplasias, characterized by bone, cartilage, and connective tissue abnormalities, often arise due to disruptions in extracellular matrix (ECM) dynamics and growth factor-dependent signaling pathways. RSPRY1, a secreted protein with RING and SPRY domains, has been implicated in bone development, yet its exact role remains to be determined.

Indexed as

OsteochondrodysplasiasSignal TransductionTransforming Growth Factor betaCell MovementExtracellular MatrixFibroblastsHumansMutationSmad3 ProteinSmad3 ProteinTransforming Growth Factor betaextracellular matrixgenome editingRSPRY1spondyloepimetaphyseal dysplasiaTGF-β signaling

Identifiers

PMID39940902

DOI10.3390/ijms26031134

PMCPMC11817781

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.