ArticleInternational journal of molecular sciences2025
CX3CR1-Fractalkine Dysregulation Affects Retinal GFAP Expression, Inflammatory Gene Induction, and LPS Response in a Mouse Model of Hypoxic Retinopathy.
Colin Rorex, Sandra M Cardona, Kaira A Church, Derek Rodriguez, Difernando Vanegas, Reina A Saldivar, Amira El-Sheikh, Yufeng Wang, Stefka Gyoneva, Anne C Cotleur and 1 more
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Colin RorexDepartment of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
Sandra M CardonaDepartment of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.ORCID 0000-0001-9128-6742
Kaira A ChurchDepartment of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.ORCID 0000-0002-3982-8476
Derek RodriguezDepartment of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
Difernando VanegasDepartment of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
Reina A SaldivarDepartment of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.
Amira El-SheikhNatural and Physical Science, Northwest Vista College, San Antonio, TX 78251, USA.
Yufeng WangDepartment of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.ORCID 0000-0002-9959-4149
Stefka GyonevaCerevel Therapeutics, Cambridge, MA 02142, USA.
Anne C CotleurBiogen, Cambridge, MA 02142, USA.
Astrid E CardonaDepartment of Molecular Microbiology and Immunology, The University of Texas at San Antonio, San Antonio, TX 78249, USA.ORCID 0000-0002-5093-8078
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
UTSA RISE Research Training ProgramR25GM060655 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI BAREA-RODRIGUEZ, EDWIN J · 2000 to 2022
$21.6M
Microglia Mediated Inflammation in the Diabetic RetinaR01EY029913 · NEI · UNIVERSITY OF TEXAS SAN ANTONIO · PI CARDONA, ASTRID E · 2019 to 2022
$1.6M
MARC at the University of Texas at San AntonioT34GM145507 · NIGMS · UNIVERSITY OF TEXAS SAN ANTONIO · PI BAREA-RODRIGUEZ, EDWIN J, CASSILL, AARON · 2022 to 2024
$1.5M
Illumina NovaSeq 6000 Sequencing SystemS10OD030311 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAI, ZHAO · 2021 to 2021
$600k
Jane and Roland Blumberg Professorship in Biology AECNCI NIH HHS P30 CA054174NEI NIH HHS R01 EY029913NIGMS NIH HHS R25 GM060655NIGMS NIH HHS T34 GM145507NIH HHS 1R01EY029913-01A1NIH HHS S10 OD030311South Texas Center for Emerging Infectious Diseases Ph.D. scholarship CR
6 · The paper itself
Abstract
Diabetic retinopathy (DR) causes vision loss due to sustained inflammation and vascular damage. The vascular damage is evident by fibrinogen leakage, angiogenesis, and hypoxia. Neuronal regulation of microglia via the CX3CL1 (Fractalkine or FKN)-CX3CR1 pathway plays a significant role in retinal pathology. Defects in FKN or CX3CR1 exacerbate inflammation, vascular damage, and vision impairment. However, the contribution of hypoxic astrocytes to the pathological process of DR is unclear. A hypoxic model (7 days of systemic 7.5% O
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
CX3CR1-Fractalkine Dysregulation Affects Retinal GFAP Expression, Inflammatory Gene Induction, and LPS Response in a Mouse Model of Hypoxic Retinopathy. · full record | OpenQuestion