Evidence map›Paper›PMID 39940875›Full record

ArticleInternational journal of molecular sciences2025

Identification of Fungal Metabolite Gliotoxin as a Potent Inhibitor Against Bacterial

Azizur Rahman, Katsuhiko Ono, Touya Toyomoto, Kenjiro Hanaoka, Tomohiro Sawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Antibacterial and Antibiofilm Activity ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  2. Serine Acetyltransferase fromInternational journal of molecular sciences · 2026
    Article
  3. iScience · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Azizur RahmanDepartment of Microbiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.ORCID 0000-0002-4700-977X
Katsuhiko OnoDepartment of Microbiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Touya ToyomotoDepartment of Microbiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
Kenjiro HanaokaGraduate School of Pharmaceutical Sciences, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan.
Tomohiro SawaDepartment of Microbiology, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.ORCID 0000-0002-7949-7309

Funding

Association for Research on Lactic Acid Bacteria Not applicableDaiichi-Sankyo Foundation of Life Science Not applicableJapan Agency for Medical Research and Development (AMED), Japan 17fm0208029h0001Kumamoto University the Program for Leading Graduate Schools, HIGO (Health Life Science: Interdisciplinary and Global Oriented) ProgramMinistry of Education, Science, Sports, and Technology (MEXT), Japan 21H05262Ministry of Education, Science, Sports, and Technology (MEXT), Japan 21H05267Ministry of Education, Science, Sports, and Technology (MEXT), Japan 22K05443Ministry of Education, Science, Sports, and Technology (MEXT), Japan 23K17979Ministry of Education, Science, Sports, and Technology (MEXT), Japan 23K25210The Chemo-Sero-Therapeutic Research Institute the Scholarship Program
6 · The paper itself

Abstract

Cysteine is an essential amino acid for sustaining life, including protein synthesis, and serves as a precursor for antioxidant glutathione. Pathogenic bacteria synthesize cysteine via a two-step enzymatic process using serine as the starting material. The first step is catalyzed by serine acetyltransferase, also known as CysE, and the second by

Indexed as

Anti-Bacterial AgentsBacterial ProteinsCysteine SynthaseEnzyme InhibitorsFungiGliotoxinCysteineHigh-Throughput Screening AssaysSalmonella typhimuriumAnti-Bacterial AgentsBacterial ProteinsCysteineCysteine SynthaseEnzyme InhibitorsGliotoxinantibacterialantimicrobial resistancecysteinegliotoxinO-acetylserine sulfhydrylase

Identifiers

PMID39940875
PMCPMC11818871

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.