Evidence map›Paper›PMID 39940818›Full record

ArticleInternational journal of molecular sciences2025

Persistent Metabolic Changes Are Induced by 24 h Low-Dose Lead (Pb) Exposure in Zebrafish Embryos.

Gwendolyn Cooper, Ryan North, Tyler Hunt-Smith, James Larson, Madison Rennie, Marguerite L Bailey, Suzanne Scarlata, Christa S Merzdorf, Brian Bothner

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Molecular and cellular mechanisms of lead-induced neurotoxicity: comparative insights from rodent and zebrafish models.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  2. Toxics · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gwendolyn CooperDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.
Ryan NorthDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717, USA.ORCID 0009-0008-8948-5572
Tyler Hunt-SmithDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717, USA.
James LarsonDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0001-9920-7682
Madison RennieDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609, USA.ORCID 0009-0005-6706-3844
Marguerite L BaileyDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0009-0002-9982-8117
Suzanne ScarlataDepartment of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609, USA.ORCID 0000-0001-5652-7467
Christa S MerzdorfDepartment of Microbiology and Cell Biology, Montana State University, Bozeman, MT 59717, USA.
Brian BothnerDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0003-1295-9609

Funding

Research Core (Developmental Research Project Program)P20GM103474 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Ann Therese Bertagnolli · 2012 to 2026
$60.0M
Ultra Performance Liquid Chromatography Tandem Mass Spectrometer for MetabolomicsS10OD028650 · OD · MONTANA STATE UNIVERSITY - BOZEMAN · PI BOTHNER, BRIAN P · 2020 to 2020
$599k
NIGMS NIH HHS P20 GM103474NIH HHS S10 OD028650U.S. National Science Foundation HRD-2054276
6 · The paper itself

Abstract

Lead (Pb) is a heavy metal associated with a range of toxic effects. Relatively few studies attempt to understand the impact of lead on development from a mechanistic perspective.

Indexed as

Embryo, NonmammalianLeadMetabolomeZebrafishAnimalsEmbryonic DevelopmentMetabolomicsLeaddevelopmentheavy metal toxicitymetabolomicsPb exposurezebrafish

Identifiers

PMID39940818
PMCPMC11817773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.