Evidence map›Paper›PMID 39940812›Full record

ArticleInternational journal of molecular sciences2025

Loss of Tyrosine Phosphatase Mu Promotes Scoliosis Progression Through Osteopontin-α5β1 Integrin Signaling and PIPK1γ90 Activity.

Mohamed Elbakry, Nasrin Khatami, Marie-Yvonne Akoume, Cédric Julien, Saadallah Bouhanik, Anita Franco, Iurie Caraus, Wesam Elremaly, Alain Moreau

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Letter to the editor concerning "MRI in early stages of adolescent idiopathic scoliosis indicates a neuro-osseous growth mismatch associated with curve progression" by S. Ohrt-Nissen (Eur spine J [2025]: doi.org/10.1007/s00586-024-08640-9).European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohamed ElbakryViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montréal, QC H3T 1C5, Canada.
Nasrin KhatamiViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montréal, QC H3T 1C5, Canada.ORCID 0000-0003-1684-7292
Marie-Yvonne AkoumeViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montréal, QC H3T 1C5, Canada.
Cédric JulienViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montréal, QC H3T 1C5, Canada.
Saadallah BouhanikViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montréal, QC H3T 1C5, Canada.
Anita FrancoViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montréal, QC H3T 1C5, Canada.
Iurie CarausViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montréal, QC H3T 1C5, Canada.
Wesam ElremalyViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montréal, QC H3T 1C5, Canada.ORCID 0000-0002-3577-3551
Alain MoreauViscogliosi Laboratory in Molecular Genetics of Musculoskeletal Diseases, Azrieli Research Center, CHU Sainte-Justine, Montréal, QC H3T 1C5, Canada.

Funding

La Fondation Yves Cotrel de l'Institut de FranceMedtronic (Canada)Mitacs IT16239Quebec Consortium for Industrial Research and Innovation in Medical Technology 12-R-SAMBAThe Montreal TransMedTech Institute
6 · The paper itself

Abstract

Adolescent idiopathic scoliosis (AIS) is characterized by a curvature of the spine affecting approximately 4% of the pediatric population, and the mechanisms driving its progression remain poorly understood. Whole-exome sequencing of a French-Canadian AIS cohort with severe scoliosis identified rare variants in the

Indexed as

OsteopontinReceptor-Like Protein Tyrosine Phosphatases, Class 5ScoliosisSignal TransductionAdolescentAnimalsDisease ProgressionFemaleHumansMaleMiceMice, KnockoutMicroRNAsOsteoblastsMicroRNAsOsteopontinReceptor-Like Protein Tyrosine Phosphatases, Class 5adolescent idiopathic scoliosisGi-coupled receptor signalingmicroRNAsOPN-α5β1 integrinosteoblastPIPK1γ90PTPRM variantsPTPµPTPµ-null micespinal deformity

Identifiers

PMID39940812
PMCPMC11816665

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.