SynthesisInternational journal of molecular sciences2025
"Omics" and Postmortem Interval Estimation: A Systematic Review.
Synthesis in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Proteomic profiling of bone for the estimation of post-mortem interval and post-mortem submersion interval: a systematic review.International journal of legal medicine · 2026Pooled it
- Artificial intelligence in forensic science: a systematic review. Part II: long-range postmortem interval estimation.International journal of legal medicine · 2026Pooled it
- Integrated renal histopathology, RNA decay, and protein degradation signatures enhance post-mortem interval prediction using machine-learning models in a veterinary forensic rat model.Veterinary world · 2026Article
- Effects of Tropical Laterite Soils on Larval Development and the Metabolome of the Forensically Important Blow FlyInsects · 2026Article
- Benefits and Limitations Associated with the Use of Alternative Biological Matrices in Forensic Toxicology, as Well as Genetic Markers of Poisoning and Psychoactive Substance Abuse.International journal of molecular sciences · 2026Review
- Application of artificial intelligence in the determination of the postmortem interval: Systematic review of the literature and metaanalysis.Forensic science, medicine, and pathology · 2026Review
- Postmortem pancreatic autolysis as a histological marker of early postmortem interval: a forensic autopsy study in a tropical setting.Forensic science international. Synergy · 2026Article
- Feasibility of an Isolated Kidney Perfusion Model for Postmortem Interval Estimation in a Rabbit Model: A Pilot Study.Diagnostics (Basel, Switzerland) · 2026Article
- FTIR Spectroscopy of Vitreous Humor for Postmortem Interval Estimation: A Multivariate Regression Approach.International journal of molecular sciences · 2026Article
- Inter-operator reliability of the total decomposition score (TDS) method for estimating the post-mortem interval (PMI) in outdoor cases.International journal of legal medicine · 2026Article
- The human metabolome and machine learning improves predictions of the post-mortem interval.Nature communications · 2026Article
- Region-resolved proteomic map of the human brain: functional interconnections and neurological implications.Signal transduction and targeted therapy · 2026Article
- Article
- Targeted metabolomics of postmortem human cardiac tissue using the Biocrates MxP Quant 500 kit.PloS one · 2026Article
- Postmortem interval estimation based on protein analysis and marker studies in different organs in vivo.Forensic science, medicine, and pathology · 2025Article
- Viral community succession during cadaver decomposition and its potential for estimating postmortem intervals.Applied and environmental microbiology · 2025Article
- Translating metabolomic evidence gathered from an animal model to a real human scenario: the post-mortem interval issue.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- A novel method for assessing postmortem interval using radon radioisotopic decay - an internal radon 'time of death clock'.Scientific reports · 2025Article
- Review
- Current Understanding and Future Research Direction for Estimating the Postmortem Interval: A Systematic Review.Diagnostics (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postmortem interval (PMI) estimation is a challenge of utmost importance in forensic daily practice. Traditional methods face limitations in accuracy and reliability, particularly for advanced decomposition stages. Recent advances in "omics" sciences, providing a holistic view of postmortem biochemical changes, offer promising avenues for overcoming these challenges. This systematic review aims at investigating the role of mass-spectrometry-based "omics" approaches in PMI estimation to elucidate molecular mechanisms underlying predictable time-dependent biochemical alterations occurring after death. A systematic search was performed, adhering to PRISMA guidelines, through "free-text" protocols in the databases PubMed, SCOPUS and Web of Science. The inclusion criteria were as follows: experimental studies analyzing, as investigated samples, animal or human corpses in toto or in parts and estimating PMI through MS-based untargeted omics approaches, with full texts in the English language. Quality assessment was performed using STROBE and ARRIVE critical appraisal checklists. A total of 1152 papers were screened and 26 included. Seventeen papers adopted a proteomic approach (65.4%), nine focused on metabolomics (34.6%) and two on lipidomics (7.7%). Most papers (57.7%) focused on short PMIs (<7 days), the remaining papers explored medium (7-120 days) (30.77%) and long PMIs (>120 days) (15.4%). Muscle tissue was the most frequently analyzed substrate (34.6% of papers), followed by liver (19.2%), bones (15.4%), cardiac blood and leaking fluids (11.5%), lung, kidney and serum (7.7%), and spleen, vitreous humor and heart (3.8%). Predictable time-dependent degradation patterns of macromolecules in different biological substrates have been discussed, with special attention to molecular insights into postmortem biochemical changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.