Evidence map›Paper›PMID 39940777›Full record

ArticleInternational journal of molecular sciences2025

Changes in Gut Microbiota According to Disease Severity in a Lupus Mouse Model.

Eui-Jeong Han, Ji-Seon Ahn, Yu-Jin Choi, Da-Hye Kim, Hea-Jong Chung

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eui-Jeong HanGwangju Center, Korea Basic Science Institute, Gwangju 61751, Republic of Korea.
Ji-Seon AhnGwangju Center, Korea Basic Science Institute, Gwangju 61751, Republic of Korea.ORCID 0000-0001-9465-2517
Yu-Jin ChoiGwangju Center, Korea Basic Science Institute, Gwangju 61751, Republic of Korea.
Da-Hye KimGwangju Center, Korea Basic Science Institute, Gwangju 61751, Republic of Korea.
Hea-Jong ChungGwangju Center, Korea Basic Science Institute, Gwangju 61751, Republic of Korea.ORCID 0000-0002-1185-7654

Funding

Korea Basic Science Institute A439111, C430000 and C442400National Research Foundation (NRF) funded by the Korean government (MSIT) No. RS-2023-00224099
6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is a multifaceted autoimmune disease driven by immune dysregulation. This study investigated the relationship between gut microbiota and lupus severity using the MRL/lpr lupus mouse model. Mice were grouped based on total immunoglobulin (Ig)G, IgG2a levels, and urine albumin-to-creatinine ratio (ACR), allowing for the comparison of gut microbiota profiles across different disease severities. Interestingly, severe lupus mice exhibited significant reductions in

Indexed as

Gastrointestinal MicrobiomeLupus Erythematosus, SystemicAnimalsDisease Models, AnimalDysbiosisFemaleImmunoglobulin GMiceMice, Inbred MRL lprSeverity of Illness IndexImmunoglobulin Gbiomarkersgut microbiotaimmune dysregulationlupus pathogenesis

Identifiers

PMID39940777
PMCPMC11817498

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.