Evidence map›Paper›PMID 39940763›Full record

ArticleInternational journal of molecular sciences2025

Optimizing Therapeutics for Intratumoral Cancer Treatments: Antiproliferative Vanadium Complexes in Glioblastoma.

Andrew C Bates, Kameron L Klugh, Anna O Galaeva, Raley A Patch, John F Manganaro, Skyler A Markham, Emma Scurek, Aviva Levina, Peter A Lay, Debbie C Crans

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrew C BatesDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-8102-8309
Kameron L KlughDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
Anna O GalaevaDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
Raley A PatchDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
John F ManganaroDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
Skyler A MarkhamDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
Emma ScurekDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
Aviva LevinaSchool of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-7311-3263
Peter A LaySchool of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-3232-2720
Debbie C CransDepartment of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0001-7792-3450

Funding

Colorado State University RSP-317-202
6 · The paper itself

Abstract

Glioblastoma, an aggressive cancer, is difficult to treat due to its location, late detection, drug resistance, and poor absorption of chemotherapeutics. Intratumoral drug administration offers a promising potential treatment alternative with localized delivery and minimal systemic toxicity. Vanadium(V) coordination complexes, incorporating Schiff base and catecholate ligands, have shown effects as antiproliferative agents with tunable efficacy and reactivity, stability, steric bulk, hydrophobicity, uptake, and toxicity optimized for the intratumoral administration vehicle. A new series of oxovanadium(V) Schiff base-catecholate complexes were synthesized and characterized using nuclear magnetic resonance (NMR), UV-Vis, and infrared spectroscopy and mass spectrometry. Stability under physiological conditions was assessed via UV-Vis spectroscopy, and the antiproliferative activity was evaluated in T98G glioblastoma and SVG p12 normal glial cells using viability assays. The newly synthesized [VO(3-tBuHSHED)(TIPCAT)] complex was more stable (

Indexed as

Antineoplastic AgentsBrain NeoplasmsCoordination ComplexesGlioblastomaVanadiumCell Line, TumorCell ProliferationCell SurvivalHumansSchiff BasesAntineoplastic AgentsCoordination ComplexesSchiff BasesVanadiumcancerglioblastomahydrophobic Schiff base scaffoldinnovative chemotherapeutic agentsintratumoral injectionoptimizing drugs for intratumoral injectionoxovanadium Schiff base catecholate complexessterically hindered catecholvanadium

Identifiers

PMID39940763
PMCPMC11817060

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.