Evidence map›Paper›PMID 39940753›Full record

ArticleInternational journal of molecular sciences2025

New Biomarkers in the Prognostic Assessment of Acute Heart Failure with Reduced Ejection Fraction: Beyond Natriuretic Peptides.

Marcelino Cortés, Jairo Lumpuy-Castillo, Camila Sofía García-Talavera, María Belén Arroyo Rivera, Lara de Miguel, Antonio José Bollas, Jose Maria Romero-Otero, Jose Antonio Esteban Chapel, Mikel Taibo-Urquía, Ana María Pello and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marcelino CortésCardiology Department, Fundación Jiménez Díaz University Hospital, 28040 Madrid, Spain.ORCID 0000-0002-2304-8547
Jairo Lumpuy-CastilloLaboratory of Diabetes and Vascular Pathology, IIS-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, Spain.ORCID 0000-0002-3458-0328
Camila Sofía García-TalaveraCardiology Department, Complejo Hospitalario San Millán-San Pedro, 26004 Logrono, La Rioja, Spain.
María Belén Arroyo RiveraCardiology Department, HM Montepríncipe University Hospital, 28660 Madrid, Spain.
Lara de MiguelCardiology Department, Fundación Jiménez Díaz University Hospital, 28040 Madrid, Spain.ORCID 0000-0002-5006-6257
Antonio José BollasCardiology Department, Fundación Jiménez Díaz University Hospital, 28040 Madrid, Spain.ORCID 0000-0003-4612-3949
Jose Maria Romero-OteroCardiology Department, Fundación Jiménez Díaz University Hospital, 28040 Madrid, Spain.
Jose Antonio Esteban ChapelCardiology Department, Fundación Jiménez Díaz University Hospital, 28040 Madrid, Spain.
Mikel Taibo-UrquíaCardiology Department, Fundación Jiménez Díaz University Hospital, 28040 Madrid, Spain.ORCID 0000-0003-2404-3657
Ana María PelloCardiology Department, Fundación Jiménez Díaz University Hospital, 28040 Madrid, Spain.
María Luisa González-CasausDepartment of Laboratory Medicine, La Paz University Hospital, 28046 Madrid, Spain.ORCID 0000-0002-1268-7191
Ignacio Mahíllo-FernándezBiostatistics and Epidemiology Unit, IIS-Fundación Jiménez Díaz, 28040 Madrid, Spain.ORCID 0000-0003-0558-6541
Oscar LorenzoLaboratory of Diabetes and Vascular Pathology, IIS-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, Spain.ORCID 0000-0001-5515-6078
José TuñónCardiology Department, Fundación Jiménez Díaz University Hospital, 28040 Madrid, Spain.ORCID 0000-0002-1373-0999

Funding

Instituto de Salud Carlos III PI20/00923; PI24/00978Ministerio de Ciencia, Innovación y Universidades RTC2019-006826-1
6 · The paper itself

Abstract

Natriuretic peptides are established biomarkers related to the prognosis of heart failure. New biomarkers have emerged in the field of cardiovascular disease. The prognostic value of these biomarkers in heart failure with reduced left ventricular ejection fraction is not well-established. We conducted a prospective, single-centre study, including (July 2019 to March 2023) 104 patients being consecutively admitted with a diagnosis of acute heart failure with reduced ejection fraction decompensation. The median follow-up was 23.5 months, during which 20 deaths (19.4%) and 21 readmissions for heart failure (20.2%) were recorded. Plasma biomarkers, such as NT-proBNP, GDF-15, sST2, suPAR, and FGF-23, were associated with an increased risk of all-cause mortality. However, a Cox regression analysis showed that the strongest predictors of mortality were an estimated glomerular filtration rate (HR 0.96 [0.93-0.98]), GDF-15 (HR 1.3 [1.16-1.45]), and sST2 (HR 1.2 [1.11-1.35]). The strongest predictive model was formed by the combination of the glomerular filtration rate and sST2 (C-index 0.758). In conclusion, in patients with acute decompensated heart failure with reduced ejection fraction, GDF-15 and sST2 showed the highest predictive power for all-cause mortality, which was superior to other established biomarkers such as natriuretic peptides. GDF-15 and sST2 may provide additional prognostic information to improve the prognostic assessment.

Indexed as

BiomarkersHeart FailureNatriuretic PeptidesStroke VolumeAcute DiseaseAgedAged, 80 and overFemaleFibroblast Growth Factor-23Glomerular Filtration RateGrowth Differentiation Factor 15HumansInterleukin-1 Receptor-Like 1 ProteinMaleMiddle AgedNatriuretic Peptide, BrainBiomarkersFGF23 protein, humanFibroblast Growth Factor-23GDF15 protein, humanGrowth Differentiation Factor 15IL1RL1 protein, humanInterleukin-1 Receptor-Like 1 ProteinNatriuretic Peptide, BrainNatriuretic PeptidesPeptide Fragmentspro-brain natriuretic peptide (1-76)biomarkersGDF 15prognosissST2systolic heart failure

Identifiers

PMID39940753
PMCPMC11817831

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.