ArticleInternational journal of molecular sciences2025
Investigation of Angiogenic Potential in CD146-Positive Stem Cells Derived from Human Exfoliated Deciduous Teeth.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Novel stem cell therapy for cerebral palsy using stem cells from human exfoliated deciduous teeth.Stem cell research & therapy · 2026Article
- Optimized delivery of RNA silencing prolyl hydroxylase domain 2 for enhanced angiogenesis and osteogenesis using bioactive glass scaffolds.Scientific reports · 2025Article
- Post-translational modifications in osteogenic differentiation of oral-derived stem cells: Mechanisms and clinical implications.World journal of stem cells · 2025Review
- In vitro pre-vascularized model of the human skin based on collagen hydrogel reinforced by fibrin-coated nanofibrous membrane.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
This study aimed to evaluate the effects of CD146, a surface antigen of mesenchymal stem cells from human exfoliated deciduous teeth (SHEDs), on angiogenic potential. SHEDs were isolated from patients' deciduous teeth and sorted into CD146-positive (CD146 + SHED) and CD146-negative (CD146 - SHED) populations. Three groups-non-sorted SHED, CD146 + SHED, and CD146 - SHED-were compared. Angiogenic potential was assessed by co-culturing each group with human umbilical vein endothelial cells (HUVECs) and evaluating lumen formation using an endothelial tube formation assay. The gene and protein expression levels of angiogenic markers, including vascular endothelial growth factor (VEGF), VEGF receptor 2 (VEGFR2), cluster of differentiation 31 (CD31), and basic fibroblast growth factor (bFGF), were analyzed using a real-time polymerase chain reaction and enzyme-linked immunosorbent assay. The tube formation assay revealed significantly enhanced angiogenic potential in CD146 + SHED and non-sorted SHED compared to CD146 - SHED. The gene and protein expression levels of VEGF, VEGFR2, CD31, and bFGF were significantly upregulated in CD146 + SHED and non-sorted SHED, highlighting superior angiogenic capabilities in CD146 + SHED. CD146 + SHED demonstrated enhanced angiogenic potential compared to CD146 - SHED, supporting their use in regenerative therapies targeting angiogenesis.
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Registered trials
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