Evidence map›Paper›PMID 39940688›Full record

ArticleInternational journal of molecular sciences2025

Polychlorinated Biphenyls Induce Cytotoxicity and Inflammation in an In Vitro Model of an Ocular Barrier.

Alessia Cosentino, Aleksandra Agafonova, Luca Cavallaro, Rosaria Ester Musumeci, Chiara Prinzi, Cinzia Lombardo, Maria Teresa Cambria, Carmelina Daniela Anfuso, Gabriella Lupo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessia CosentinoDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0009-0008-1709-5874
Aleksandra AgafonovaDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-8253-0598
Luca CavallaroDepartment of Civil Engineering and Architecture, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-9356-7289
Rosaria Ester MusumeciDepartment of Civil Engineering and Architecture, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-1022-0571
Chiara PrinziDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0009-0003-9920-8310
Cinzia LombardoDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.
Maria Teresa CambriaDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-7541-656X
Carmelina Daniela AnfusoDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0001-7951-1812
Gabriella LupoDepartment of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy.ORCID 0000-0002-9291-6969

Funding

NOP Research and Innovation 2014-2020 under Axis II "Thematic Projects", Action "Clusters" B64I20000330005
6 · The paper itself

Abstract

Polychlorinated biphenyls (PCBs) are heterogeneous, synthetic, and widespread organochlorine compounds, and are one of the persistent organic pollutants present in improperly dumped waste and electronic equipment (e-waste), with a high bioaccumulation potential. In this study, the toxicity of Aroclor 1254 (a mixture of commercial PCBs) in human corneal epithelial cells (HCEpiCs), in an in vitro model of an ocular barrier, was evaluated. Aroclor 1254 (0.1-10 μg/mL) reduced cell viability, trans-endothelial electric resistance (TEER) and cell migration. Moreover, it induced an inflammatory response, as indicated by the increase in cPLA

Indexed as

CorneaInflammationPolychlorinated BiphenylsCell LineCell MovementCell SurvivalCytokinesEpithelial CellsEpithelium, CornealHumansCytokinesPolychlorinated BiphenylsAroclor 1254interleukin 1β (IL-1β)mitogen-activated protein (MAP) kinasenuclear factor NF-kBphospholipase A2polychlorinated biphenylsprostaglandins E2transforming growth factor βtumor necrosis factor α

Identifiers

PMID39940688
PMCPMC11817744

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.