Evidence map›Paper›PMID 39940679›Full record

ArticleInternational journal of molecular sciences2025

Genetic Prοpensity for Different Aspects of Dementia Pathology and Cognitive Decline in a Community Elderly Population.

Stefanos N Sampatakakis, Niki Mourtzi, Alex Hatzimanolis, Georgios Koutsis, Sokratis Charisis, Iliana Gkelmpesi, Eirini Mamalaki, Eva Ntanasi, Alfredo Ramirez, Mary Yannakoulia and 5 more

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Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Stefanos N Sampatakakis1st Department of Neurology, Aiginition Hospital, Athens Medical School, National and Kapodistrian University, 11528 Athens, Greece.ORCID 0009-0009-7316-0471
Niki Mourtzi1st Department of Neurology, Aiginition Hospital, Athens Medical School, National and Kapodistrian University, 11528 Athens, Greece.
Alex HatzimanolisDepartment of Psychiatry, Aiginition Hospital, Athens Medical School, National and Kapodistrian University, 11528 Athens, Greece.
Georgios KoutsisNeurogenetics Unit, 1st Department of Neurology, Aiginition Hospital, Athens Medical School, National and Kapodistrian University, 11528 Athens, Greece.ORCID 0000-0002-8980-8377
Sokratis CharisisDepartment of Neurology, UT Health San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0001-6578-393X
Iliana Gkelmpesi1st Department of Neurology, Aiginition Hospital, Athens Medical School, National and Kapodistrian University, 11528 Athens, Greece.
Eirini Mamalaki1st Department of Neurology, Aiginition Hospital, Athens Medical School, National and Kapodistrian University, 11528 Athens, Greece.
Eva Ntanasi1st Department of Neurology, Aiginition Hospital, Athens Medical School, National and Kapodistrian University, 11528 Athens, Greece.
Alfredo RamirezDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, 50923 Cologne, Germany.ORCID 0000-0003-4991-763X
Mary YannakouliaDepartment of Nutrition and Dietetics, Harokopio University, 17676 Athens, Greece.ORCID 0000-0003-2171-7337
Mary H KosmidisLaboratory of Neuropsychology and Behavioral Neuroscience, School of Psychology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-8790-1220
Efthimios DardiotisDepartment of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41334 Larissa, Greece.ORCID 0000-0003-2957-641X
Georgios HadjigeorgiouDepartment of Neurology, Medical School, University of Cyprus, 1678 Nicosia, Cyprus.
Paraskevi SakkaAthens Association of Alzheimer's Disease and Related Disorders, 11636 Marousi, Greece.
Nikolaos Scarmeas1st Department of Neurology, Aiginition Hospital, Athens Medical School, National and Kapodistrian University, 11528 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, we investigated the association of genetic predisposition with specific dimensions of dementia pathophysiology for global and domain-specific cognitive decline in older adults. The sample was drawn from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD) study, comprising 512 cognitively normal individuals over 64 years of age, with a mean follow-up of 2.9 years. Cognitive function was evaluated through a neuropsychological test battery, while genetic predisposition was assessed based on two distinct Polygenic Risk Scores (PRS) for amyloid-beta 42 (Aβ

Indexed as

Cognitive DysfunctionDementiaGenetic Predisposition to DiseaseAgedAged, 80 and overAgingAmyloid beta-PeptidesFemaleHumansLongitudinal StudiesMaleMiddle AgedMultifactorial InheritanceNeuropsychological TestsPeptide FragmentsWhite MatterAmyloid beta-Peptidesamyloid beta-protein (1-42)Peptide Fragmentsamyloid betacognitive declinedementiapathophysiologypolygenic risk scorewhite matter hyperintensities

Identifiers

PMID39940679
PMCPMC11817854

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.