Evidence map›Paper›PMID 39940585›Full record

ArticlePolymers2025

3D Porous Polycaprolactone with Chitosan-Graft-PCL Modified Surface for In Situ Tissue Engineering.

Johannes Pitts, Robert Hänsch, Yvonne Roger, Andrea Hoffmann, Henning Menzel

Abstract read
In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Johannes PittsInstitute for Technical Chemistry, Braunschweig University of Technology, 38106 Braunschweig, Germany.ORCID 0009-0002-0232-0828
Robert HänschInstitute of Plant Biology, Braunschweig University of Technology, 38106 Braunschweig, Germany.
Yvonne RogerHannover Medical School, Department of Orthopaedic Surgery, Biological Basics for Biohybrid Implants, 30625 Hannover, Germany.ORCID 0000-0002-8775-5320
Andrea HoffmannHannover Medical School, Department of Orthopaedic Surgery, Biological Basics for Biohybrid Implants, 30625 Hannover, Germany.ORCID 0000-0003-2318-8985
Henning MenzelInstitute for Technical Chemistry, Braunschweig University of Technology, 38106 Braunschweig, Germany.ORCID 0000-0002-4915-7311

Funding

Deutsche Forschungsgemeinschaft HO 2058/15-2: 269986331 and ME1057/19-2, AOBJ: 650610
6 · The paper itself

Abstract

Tissue engineering has emerged as a promising approach for improved regeneration of native tissue and could increase the quality of life of many patients. However, the treatment of injured tissue transitions is still in its early stages, relying primarily on a purely physical approach in medical surgery. A biodegradable implant with a modified surface that is capable of biological active protein delivery via a nanoparticulate release system could advance the field of musculoskeletal disorder treatments enormously. In this study, interconnected 3D macroporous scaffolds based on Polycaprolactone (PCL) were fabricated in a successive process of blending, annealing and leaching. Blending with varying parts of Polyethylene oxide (PEO), NaCl and (powdered) sucrose and altering processing conditions yielded scaffolds with a huge variety of morphologies. The resulting unmodified hydrophobic scaffolds were modified using two graft polymers (CS-g-PCL

Indexed as

chitosan-graft-PCLin situ tissue engineeringin vitro cell testingmacroporous scaffoldPCLPEOpolymer blendingporositysucrosesurface modificationsurface potentialTGF release

Identifiers

PMID39940585
PMCPMC11820431

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.