ArticlePolymers2025
Development of a Chitosan-Silver Nanocomposite/β-1,3-Glucan/Hyaluronic Acid Composite as an Antimicrobial System for Wound Healing.
Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Progress in Hyaluronan-Based Nanoencapsulation Systems for Smart Drug Release and Medical Applications.Molecules (Basel, Switzerland) · 2025Review
- Review
- Antifungal Nanocomposites from Honeybee Chitosan and Royal Jelly-Mediated Nanosilver for Suppressing Biofilm and Hyphal Formation ofPolymers · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An ideal wound dressing should be biocompatible, exhibit high antibacterial activity, and promote blood coagulation in the wound. In this study, we used chitosan as a multifunctional template to synthesize silver nanoparticles embedded in chitosan (Ag NP@CHI), which were then combined with β-1,3-glucan/hyaluronic acid (HA) to form an Ag NP@CHI/β-1,3-glucan/HA composite material with biocompatibility, wound healing-promoting properties, and antibacterial activity. A high concentration of chitosan led to the formation of smaller crystalline structures of Ag NPs and improved their dispersion within the chitosan matrix, but decreased their antibacterial potency. The Ag NP@CHI prepared with 1.0 mg/mL chitosan had the smallest particle size and good antibacterial activity. Compared to Ag NP@CHI, the prepared Ag NP@CHI/β-1,3-glucan/HA composite significantly enhanced biocompatibility, cell migration, hemocompatibility, and blood coagulation, with a minor reduction in antibacterial efficiency due to restricted ionic silver release and diffusion. With its high biocompatibility, hemocompatibility, promotion of blood coagulation and wound healing, and antibacterial efficiency, Ag NP@CHI@β-1,3-glucan/HA demonstrates potential as a wound healing composite in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.