Evidence map›Paper›PMID 39940377›Full record

ReviewNutrients2025

Research Progress on the Degradation of Human Milk Oligosaccharides (HMOs) by Bifidobacteria.

Ruitao Cai, Jie Zhang, Yingte Song, Xiaoyong Liu, Huilian Xu

Abstract readReview
In one paragraph

Review in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruitao CaiSchool of Biological Science and Technology, University of Jinan, Jinan 250024, China.
Jie ZhangSchool of Biological Science and Technology, University of Jinan, Jinan 250024, China.
Yingte SongSchool of Biological Science and Technology, University of Jinan, Jinan 250024, China.
Xiaoyong LiuSchool of Biological Science and Technology, University of Jinan, Jinan 250024, China.
Huilian XuSchool of Biological Science and Technology, University of Jinan, Jinan 250024, China.

Funding

Discipline Construction, University of Jinan (514-1420707)the National Science Foundation of Shandong Province (SZR2466)
6 · The paper itself

Abstract

The purpose of this study was to investigate the degradation mechanism of Bifidobacterium on breast milk oligosaccharides (HMOs) and its application in infant nutrition. The composition and characteristics of HMOs were introduced, and the degradation mechanism of HMOs by Bifidobacterium was described, including intracellular and extracellular digestion and species-specific differences. The interaction between Bifidobacterium and Bacteroides in the process of degrading HMOs and its effect on intestinal microecology were analyzed. The effects of HMO formula milk powder on the intestinal microbiota of infants were discussed, including simulating breast milk composition, regulating intestinal flora and immune function, infection prevention, and brain development. Finally, the research results are summarized, and future research directions are proposed to provide directions for research in the field of infant nutrition.

Indexed as

BifidobacteriumMilk, HumanOligosaccharidesGastrointestinal MicrobiomeHumansInfantInfant FormulaInfant, NewbornInfant Nutritional Physiological PhenomenaOligosaccharidesBifidobacteriadegradation mechanismHMOsinfant nutrition

Identifiers

PMID39940377
PMCPMC11820314

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.