Evidence map›Paper›PMID 39940302›Full record

SynthesisNutrients2025

The Influence of Dietary Supplements on Exercise-Induced Gut Damage and Gastrointestinal Symptoms: A Systematic Review and Meta-Analysis.

Robyn Aitkenhead, Mark Waldron, Gillian E Conway, Katy Horner, Shane M Heffernan

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Robyn AitkenheadA-STEM Centre, Faculty of Science and Engineering, Swansea University, Swansea SA1 8EN, UK.
Mark WaldronA-STEM Centre, Faculty of Science and Engineering, Swansea University, Swansea SA1 8EN, UK.ORCID 0000-0002-2720-4615
Gillian E ConwayIn Vitro Toxicology Group, Institute of Life Science, Swansea University Medical School, Swansea SA2 8PP, UK.ORCID 0000-0002-5991-0960
Katy HornerSchool of Public Health, Physiotherapy and Sport Science, University College, Belfield, D04 V1W8 Dublin, Ireland.ORCID 0000-0002-5046-3658
Shane M HeffernanA-STEM Centre, Faculty of Science and Engineering, Swansea University, Swansea SA1 8EN, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endurance exercise, especially under heat stress, temporarily compromises the integrity of the intestinal barrier in healthy individuals. Consequently, there is growing interest in developing effective dietary strategies to alleviate exercise-induced gastrointestinal symptoms and gut damage. This meta-analysis investigated the effects of dietary supplements on mitigating these challenges. The search was performed in November 2024 following PRISMA guidelines, and 26 peer-reviewed studies were included across three meta-analyses: (1) gastrointestinal symptoms, (2) circulating intestinal fatty acid-binding protein (i-FABP), and (3) exercise performance. The moderating effect of variables was assessed via sub-group analysis and meta-regression. Overall, there was no pooled effect of supplement interventions on gastrointestinal symptoms (Hedges' g = 0.42, 95% CI -0.17: 1.02,

Indexed as

Dietary SupplementsExerciseGastrointestinal DiseasesGastrointestinal TractAdultFatty Acid-Binding ProteinsFemaleHumansMaleProbioticsFatty Acid-Binding Proteinsexercisegut damageheatsupplements

Identifiers

PMID39940302
PMCPMC11820470

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.