Evidence map›Paper›PMID 39940261›Full record

Trial reportNutrients2025

Impact of L-Citrulline Supplementation and HIIT on Lipid Profile, Arterial Stiffness, and Fat Mass in Obese Adolescents with Metabolic-Dysfunction-Associated Fatty Liver Disease: A Randomized Clinical Trial.

Alan Arturo Rodríguez-Carrillo, Mario Ramón Espinoza-Vargas, Katya Vargas-Ortiz, Lorena Del Rocío Ibarra-Reynoso, Monserrat Olvera-Juárez, Armando Gómez-Ojeda, Ma Eugenia Garay-Sevilla, Arturo Figueroa

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05778266 (Effect of L-citrulline and HIIT on Arterial Stiffness, Body Composition, and Lipid Profile in Adolescents with Steatosis Associated with Metabolic Dysfunction), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05778266 nacompletednot on this map

Effect of L-citrulline and HIIT on Arterial Stiffness, Body Composition, and Lipid Profile in Adolescents with Steatosis Associated with Metabolic Dysfunction (MASLD)

TypeinterventionalSponsorUniversidad de GuanajuatoRan2023 to 2024Enrolled43ConditionsMetabolic Dysfunction-Associated Fatty Liver Disease, Obesity, Adolescent, Arterial StiffnessArmsL-citrulline, Carboxymethyl cellulose, High Intensity Intervals Training
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alan Arturo Rodríguez-CarrilloDepartment of Medical Sciences, Division of Health Sciences, University of Guanajuato, Campus León, León CP. 37320, Guanajuato, Mexico.
Mario Ramón Espinoza-VargasDepartment of Medical Sciences, Division of Health Sciences, University of Guanajuato, Campus León, León CP. 37320, Guanajuato, Mexico.
Katya Vargas-OrtizDepartment of Medical Sciences, Division of Health Sciences, University of Guanajuato, Campus León, León CP. 37320, Guanajuato, Mexico.
Lorena Del Rocío Ibarra-ReynosoDepartment of Medical Sciences, Division of Health Sciences, University of Guanajuato, Campus León, León CP. 37320, Guanajuato, Mexico.ORCID 0000-0002-6119-1328
Monserrat Olvera-JuárezDepartment of Medical Sciences, Division of Health Sciences, University of Guanajuato, Campus León, León CP. 37320, Guanajuato, Mexico.
Armando Gómez-OjedaDepartment of Medical Sciences, Division of Health Sciences, University of Guanajuato, Campus León, León CP. 37320, Guanajuato, Mexico.
Ma Eugenia Garay-SevillaDepartment of Medical Sciences, Division of Health Sciences, University of Guanajuato, Campus León, León CP. 37320, Guanajuato, Mexico.
Arturo FigueroaDepartment of Kinesiology and Sport Management, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0001-9710-038X

Funding

La Cantera Desarrollos Mineros de Guanajuato NoneUniversidad de Guanajuato None
6 · The paper itself

Abstract

backgroundMetabolic-dysfunction-associated steatotic liver disease (MASLD) and obesity contribute to vascular dysfunction through oxidative stress, heightening cardiovascular risk. Oral supplementation with L-citrulline (L-cit), a precursor of L-arginine (L-arg) and nitric oxide, and high-intensity interval training (HIIT) may improve vascular function and cardiometabolic health.

objectivesThis study aimed to evaluate the combined effects of L-cit supplementation and HIIT on arterial stiffness, body composition, glucose metabolism, lipid profile, and blood pressure (BP) in adolescents with MASLD and obesity.

methodsIn this double-blind, placebo-controlled, randomized clinical trial (ClinicalTrials.gov (NCT05778266), 44 adolescents (15-19 years) with MASLD and obesity were assigned to HIIT + L-cit (n = 14), HIIT + placebo (n = 14), or L-cit (n = 15) for 12 weeks. HIIT sessions (85% and 60% peak heart rate during intense and recovery periods) occurred thrice weekly. Training volume progressively increased, and participants performed 20 min of HITT per session in the last 8 weeks.

resultsOutcomes included pulse wave velocity (PWV), augmentation index (Aix75), VO2peak, body composition, BP, glucose and lipid profiles, and hepatic steatosis. Compared to L-cit, HIIT + L-cit improved non-high-density lipoprotein cholesterol (

conclusionsHIIT + L-cit supplementation enhanced lipid profile and cardiorespiratory fitness, while HIIT + placebo improved cardiorespiratory capacity, and L-cit alone decreased hepatic steatosis. Thus, L-cit could be an adjuvant strategy to manage obesity-related MASLD in adolescents.

Indexed as

CitrullineDietary SupplementsFatty LiverHigh-Intensity Interval TrainingLipidsPediatric ObesityVascular StiffnessAdolescentBlood PressureBody CompositionDouble-Blind MethodFemaleHumansMaleObesityPulse Wave AnalysisCitrullineLipidsadolescentsarterial stiffnessHIITL-citrullineMASLD

Identifiers

PMID39940261
PMCPMC11820369

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.