Evidence map›Paper›PMID 39940189›Full record

ArticleNanomaterials (Basel, Switzerland)2025

Safety of Mechanically Fibrillated Cellulose Nanofibers (CNFs) by Inhalation Exposure Based on TG412.

Yoshihiro Yamashita, Akinori Tokunaga, Koji Aoki, Tamotsu Ishizuka, Satoshi Fujita, Shuichi Tanoue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yoshihiro YamashitaResearch Center for Fibers and Materials, University of Fukui, 3-9-1 Bunkyo, Fukui 910-8507, Japan.ORCID 0009-0000-8498-5203
Akinori TokunagaLife Science Research Laboratory, School of Medical Sciences, University of Fukui, 23-3, Matsuokashimoaizuki, Eiheiji-cho, Fukui 910-1193, Japan.
Koji AokiDepartment of Pharmacology, Faculty of Medicine, University of Fukui, 23-3, Matsuokashimoaizuki, Eiheiji-cho, Fukui 910-1193, Japan.ORCID 0000-0001-5854-7015
Tamotsu IshizukaDepartment of Respiratory Medicine, Faculty of Medical Sciences, University of Fukui, 23-3, Matsuokashimoaizuki, Eiheiji-cho, Fukui 910-1193, Japan.ORCID 0000-0002-8347-3553
Satoshi FujitaDepartment of Frontier Fiber Technology and Science, Faculty of Engineering, University of Fukui, 3-9-1 Bunkyo, Fukui 910-8507, Japan.ORCID 0000-0003-1438-6402
Shuichi TanoueResearch Center for Fibers and Materials, University of Fukui, 3-9-1 Bunkyo, Fukui 910-8507, Japan.

Funding

New Energy and Industrial Technology Development Organization No. 20001602-0
6 · The paper itself

Abstract

An investigation into the acute toxicity of mechanically fibrillated cellulose nanofibers (fib-CNFs), with a fiber length ranging from 500 to 600 nm, was conducted in accordance with the OECD TG412 guidelines. In this study, rats were exposed to fib-CNFs via nasal inhalation for 6 h daily over a 28-day period. The highest exposure concentration was set at 35 mg/m

Indexed as

fib-CNFsinhalation exposurein-vivoNOAELOECD TG412rat

Identifiers

PMID39940189
PMCPMC11819688

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.