ReviewNanomaterials (Basel, Switzerland)2025
A Review of the Carcinogenic Potential of Thick Rigid and Thin Flexible Multi-Walled Carbon Nanotubes in the Lung.
Review in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Dose-Response Relationships for Lung Tumor and Pleural Mesothelioma Induction by Repetitive Intratracheal Instillation of a Multiwalled Carbon Nanotube, MWCNT-7, in Rats: Comparison with Inhalation Carcinogenicity Based on Lung Burden.Nanomaterials (Basel, Switzerland) · 2026Article
- Comparative Gene Expression Analysis of Malignant Mesothelioma and Lung Adenocarcinomas Induced by Multi-Walled Carbon Nanotube-7 and Double-Walled Carbon Nanotubes in Rats: Distinct Molecular Signatures and Canonical Pathways.Nanomaterials (Basel, Switzerland) · 2025Article
- Comparative Carcinogenicity of Double-Walled Carbon Nanotubes of Different Lengths Administered by Intratracheal Installation into Rat Lungs.Nanomaterials (Basel, Switzerland) · 2025Article
- Carbon Nanomaterials in Biomedicine: Opportunities and Toxicological Concerns.International journal of nanomedicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The carcinogenic potential of MWCNTs is not well defined. Currently, IARC has classified MWCNT-7 as a Group 2 B material, possibly carcinogenic to humans, and all other MWCNTs as Group 3 materials, inadequate evidence in experimental animals for their carcinogenicity and not classifiable as to their carcinogenicity to humans. In this review we discuss studies that investigated the lung toxicity of well characterized MWCNTs in mice and rats. Intraperitoneal and intrascrotal injection studies identified rigid MWCNTs as hazardous materials. The assessment of lung toxicity of MWCNTs in short and medium term instillation and inhalation studies were not conclusive; therefore, these studies do not confirm the hazard of MWCNTs. However, two-year carcinogenicity studies indicate that MWCNT-7 and other MWCNTs, both thick rigid MWCNTs and thin flexible MWCNTs, are carcinogenic in test animals. Therefore, the carcinogenicity of MWCNTs in experimental animals should be reassessed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.