ArticleTropical medicine and health2025
Susceptibility of Anopheles gambiae s.l. to the neonicotinoid insecticide clothianidin in eighteen sites located along the south-north transect of Benin.
Article in Tropical medicine and health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Pyrethroid resistance intensity and preserved susceptibility to novel insecticides in Anopheles gambiae s.l. along a south-north transect in Benin.Tropical medicine and health · 2026Article
- Impact of indoor residual spraying and insecticide-treated nets on malaria burden in 8 districts in West Nile and Acholi regions, Uganda: a quasi-experimental study.BMC global and public health · 2026Article
- Anopheles coluzzii from Sakassou, Central Côte d'Ivoire show aggravated resistance to pyrethroids and organophosphate but are fully susceptible to clothianidin.Parasites & vectors · 2026Article
- Detection of reduced susceptibility of Anopheles Gambiae s.l. to pirimiphos-methyl in Benin.Scientific reports · 2026Article
- Metabolic resistance drives cross-resistance in Aedes albopictus to pyriproxyfen and pyrethroid insecticides.PloS one · 2026Article
- Susceptibility of the invasive malaria vector Anopheles stephensi in Ethiopia to novel chemical insecticides and insect growth regulator.Scientific reports · 2025Article
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15 authors.
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Abstract
backgroundThe widespread resistance of malaria vectors to traditional neurotoxic insecticides has stimulated the search for new insecticide classes with novel modes of action. For that, the present study was designed to collect data on the susceptibility of field-collected Anopheles gambiae sensu lato (s.l.) to clothianidin, a neonicotinoid insecticide used in agriculture and that recently received WHO approval for use in indoor residual spraying.
methodsAn. gambiae s.l. were collected as larvae and pupae from 18 sites located along the south-north transect of Benin, and reared to adulthood. Female mosquitoes aged 2-5 days were exposed to clothianidin-impregnated papers (2% weight by volume (w/v) of SumiShield™ 50WG dissolved in distilled water). Due to the delayed action of clothianidin, mortality was daily recorded over 7 days. Polymerase chain reaction was used to assess the molecular species composition in the An. gambiae s.l. complex and the frequency of knockdown resistance (kdr) and insensitive acetylcholinesterase (Ace-1
resultsMortality rates of field-collected An. gambiae s.l. were very high (≥98%) between 2- and 7-day post-exposure, indicating full susceptibility to clothianidin. Molecular species identification revealed the presence of An. coluzzii (53.7%), An. gambiae sensu stricto (s.s.) (42.5%), and An. arabiensis (3.8%) in the An. gambiae s.l. complex. kdr and Ace-1
conclusionsFindings of the present study indicates that An. gambiae s.l. populations collected along the north-south transect of Benin remain susceptible to clothianidin. This broadens the portfolio of indoor residual spraying products that the national malaria control programme can deploy to better control pyrethroid-resistant populations of vectors.
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