Evidence map›Paper›PMID 39940029›Full record

ArticleEuropean journal of medical research2025

Long non-coding RNA H19 promotes cervical cancer development via targeting the microRNA-140/ALDH1A1 axis.

Jie Ming, Fang Cheng, Yating Fu, Meng Zhang, Qian Rou, Kaixiong Liu, Zinati Nuertai, Shanshan Xu, Ling Tao, Alfira Abudujapar and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jie MingMedical Imaging Center, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
Fang ChengDepartment of Special Needs Comprehensive, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
Yating FuDepartment of Radiology, Urumqi Stomatological Hospital, Urumqi, 830002, Xinjiang, China.
Meng ZhangDepartment of Special Needs Comprehensive, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
Qian RouDepartment of Special Needs Comprehensive, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
Kaixiong LiuDepartment of Oncology, Bachu County People's Hospital, Bachu, 843800, Xinjiang, China.
Zinati NuertaiDepartment of Special Needs Comprehensive, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
Shanshan XuDepartment of Special Needs Comprehensive, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
Ling TaoDepartment of Gynecology, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
Alfira AbudujaparAffiliated Cancer Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China.
Ying LiuDepartment of Special Needs Comprehensive, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, 830011, Xinjiang, China. lydiasunshine@xjmu.edu.cn.

Funding

General project of the Natural Science Foundation of Xinjiang UygurAutonomous Region 2022D01A01
6 · The paper itself

Abstract

backgroundDysregulation of long non-coding RNA H19 (lncRNA H19) is involved in cervical cancer (CC) progression. This study aims to unveil the specific role and relevant mechanism of lncRNA H19 in CC.

methodsThe expression of lncRNA H19 in CC cells was detected by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). CC cells were transfected with sh-H19, followed by cell proliferation, apoptosis, migration and invasion were examined. After location of H19 in cells using fluorescence in Situ Hybridization (FISH), target microRNAs (miRNAs) and genes associated with lncRNA H19 were predicted using bioinformatics analysis and validated by dual-luciferase reporter assay. Finally, the specific role of lncRNA H19 in CC was explored in vivo.

resultsThe upregulation of lncRNA H19 was observed in CC cells. LncRNA H19 knockdown inhibited the proliferation, migration, and invasion of CC cells, and remarkably promoted CC cell apoptosis. LncRNA H19 was localized in the nucleus and interacted with miR-140 that was downregulated in CC cells. MiR-140 inhibition reversed the effects of lncRNA H19 knockdown on CC cell development. MiR-140 targets ALDH1A1, and lncRNA H19 knockdown decreased the ALDH1A1 expression, which was rescued by miR-140 inhibition. In vivo experiments also shown that reduction of lncRNA H19 diminishes tumor growth via targeting the miR-140/ALDH1A1 axis.

conclusionLncRNA H19 promotes the malignant progression of CC through targeting miR-140/ALDH1A1 axis.

Indexed as

Aldehyde Dehydrogenase 1 FamilyMicroRNAsRetinal DehydrogenaseRNA, Long NoncodingUterine Cervical NeoplasmsAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMiceMice, NudeAldehyde Dehydrogenase 1 FamilyALDH1A1 protein, humanH19 long non-coding RNAMicroRNAsMirn140 microRNA, humanRetinal DehydrogenaseRNA, Long NoncodingAldehyde dehydrogenase 1A1Cervical cancerCompeting endogenous RNALncRNA H19MicroRNA-140

Identifiers

PMID39940029
PMCPMC11823256

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.