Evidence map›Paper›PMID 39939842›Full record

ArticleBMC oral health2025

Resveratrol modulates phosphorylation of ERK and AKT in murine cementoblasts during in vitro orthodontic compression.

Shams Negm, Michael Wolf, Rogerio B Craveiro, Leon Schurgers, Joachim Jankowski, Rebekka K Schneider, Marta Rizk, Franziska Coenen, Isabel Knaup, Sihem Brenji and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shams Negm *Department of Orthodontics, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Michael Wolf *Department of Orthodontics, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Rogerio B CraveiroDepartment of Orthodontics, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Leon SchurgersDepartment of Biochemistry, CARIM, University of Maastricht, Maastricht, the Netherlands.
Joachim JankowskiInstitute of Molecular Cardiovascular Research, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Rebekka K SchneiderDepartment of Cell and Tumor Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Marta RizkDepartment of Orthodontics, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Franziska CoenenDepartment of Orthodontics, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Isabel KnaupDepartment of Orthodontics, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Sihem BrenjiDepartment of Orthodontics, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Christian NiederauDepartment of Orthodontics, Medical Faculty, RWTH Aachen University, Aachen, Germany. cniederau@ukaachen.de.

Funding

Deutsche Forschungsgemeinschaft Project-ID 504777725
6 · The paper itself

Abstract

objectiveResveratrol is a plant polyphenol known for its anti-inflammatory and pro-regenerative properties. These could be beneficial in controlling potential side effects of orthodontic treatment, such as apical root resorption. Orthodontic tooth movement occurs as part of a sterile inflammatory response. However, dysregulation of this process can result in pathologically increased osteoclast activity in the radicular vicinity, leading to unwanted root resorption. Previous studies have shown that root cementum cells can modulate recruitment of osteoclast precursors and cementum repair. MATERIAL AND

methodsWe investigated the effect of resveratrol on mechanically stimulated murine cementoblasts (OCCM-30) with regards to cell viability, and mRNA expression and protein levels of pro-inflammatory cytokines. Furthermore, the modulation of central related kinases was investigated.

resultsResveratrol increased viability of OCCM-30 in a time- and dose-dependent manner and significantly reduced upregulation of pERK and pAKT, upstream regulators of key cellular metabolic pathways. Furthermore, we describe for the first time that cementoblasts respond to compression with accelerated activation of STAT3 and increased translocation of NF-κB p65 into the nucleus.

conclusionThis study shows a regulation of pAKT and pERK by resveratrol in OCCM-30 cells without a negative effect on cell viability. Therefore, resveratrol may have the potential to modulate the periodontal response to mechanical stimulation.

Indexed as

Dental CementumExtracellular Signal-Regulated MAP KinasesProto-Oncogene Proteins c-aktStilbenesTooth Movement TechniquesAnimalsCell LineCell SurvivalCytokinesMicePhosphorylationResveratrolSTAT3 Transcription FactorCytokinesExtracellular Signal-Regulated MAP KinasesProto-Oncogene Proteins c-aktResveratrolSTAT3 Transcription FactorStilbenesCompressionInflammationMechanical stimulationOCCM-30Orthodontically induced inflammatory root resorptionOrthodontic tooth movementSterile inflammation

Identifiers

PMID39939842
PMCPMC11823246

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.