Evidence map›Paper›PMID 39939817›Full record

ArticleCellular & molecular immunology2025

Uncovering two neutrophil-committed progenitors that immediately precede promyelocytes during human neutropoiesis.

Ilaria Signoretto, Federica Calzetti, Giulia Finotti, Silvia Lonardi, Camillo Balanzin, Francisco Bianchetto-Aguilera, Sara Gasperini, Elisa Gardiman, Monica Castellucci, Anna Russignan and 7 more

Abstract read
In one paragraph

Article in Cellular & molecular immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. A who's who of cell types in skeletal muscle.Communications biology · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Acta pharmaceutica Sinica. B · 2026
    Article
  6. Review
  7. Myeloid metabolism and its role in immunotherapy of cancer.Journal for immunotherapy of cancer · 2025
    Review
  8. On the origin of neutrophils.Cellular & molecular immunology · 2025
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ilaria Signoretto *Department of Medicine, Section of General Pathology, University of Verona, Verona, Italy.
Federica Calzetti *Department of Medicine, Section of General Pathology, University of Verona, Verona, Italy.
Giulia Finotti *Centro Piattaforme Tecnologiche, University of Verona, Verona, Italy.
Silvia LonardiDepartment of Molecular and Translational Medicine, Unit of Pathology, University of Brescia, Brescia, Italy.
Camillo BalanzinDepartment of Medicine, Section of General Pathology, University of Verona, Verona, Italy.
Francisco Bianchetto-AguileraDepartment of Medicine, Section of General Pathology, University of Verona, Verona, Italy.
Sara GasperiniDepartment of Medicine, Section of General Pathology, University of Verona, Verona, Italy.
Elisa GardimanDepartment of Medicine, Section of General Pathology, University of Verona, Verona, Italy.ORCID 0000-0002-5431-9610
Monica CastellucciCentro Piattaforme Tecnologiche, University of Verona, Verona, Italy.
Anna RussignanDepartment of Engineering for innovation medicine, University of Verona, Verona, Italy.
Massimiliano BonifacioDepartment of Engineering for innovation medicine, University of Verona, Verona, Italy.
Antonio SicaDepartment of Pharmaceutical Sciences, University of Piemonte Orientale 'A. Avogadro', Novara//Humanitas Clinical and Research Center, Rozzano, Italy.ORCID 0000-0002-8342-7442
William VermiDepartment of Molecular and Translational Medicine, Unit of Pathology, University of Brescia, Brescia, Italy.ORCID 0000-0002-2291-2997
Cristina TecchioDepartment of Engineering for innovation medicine, University of Verona, Verona, Italy.
Patrizia ScapiniDepartment of Medicine, Section of General Pathology, University of Verona, Verona, Italy.
Nicola TamassiaDepartment of Medicine, Section of General Pathology, University of Verona, Verona, Italy.ORCID 0000-0003-2990-3003
Marco A CassatellaDepartment of Medicine, Section of General Pathology, University of Verona, Verona, Italy. marco.cassatella@univr.it.ORCID 0000-0001-7824-1806

Funding

Associazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research) IG-27613Ministero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) PRIN20227YR8AWMinistero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) PRIN2022W839FM
6 · The paper itself

Abstract

Technological advances have greatly improved our knowledge of myelopoiesis, for example, with the discovery of granulocyte‒monocyte‒dendritic cell (DC) progenitors (GMDPs), monocyte‒DC progenitors (MDPs), common DC progenitors (CDPs) and common monocyte progenitors (cMoPs) on the basis of flow cytometry approaches. Concomitantly, some progress has been made in characterizing the very early phases of human neutropoiesis with the description of novel CD66b

Indexed as

NeutrophilsStem CellsAntigens, CDCell DifferentiationCell LineageHumansMyelopoiesisAntigens, CDChronic myeloid leukemiaG-CSFNeutrophil progenitorsNeutrophilsNeutropoiesis

Identifiers

PMID39939817
PMCPMC11868371

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.