ArticleNature2025
Topological segregation of stress sensors along the gut crypt-villus axis.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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18citing papers in PubMed, 1 pooled it
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evolution and hotspots in breast cancer organoid research: insights from a bibliometric and visual knowledge mapping study (2005-2024).Frontiers in oncology · 2025Pooled it
- Gut Microbiota-Mediated Modulation of Intestinal Serotonin by Tea Polyphenols: Potential Mechanisms and Implications for Metabolic Health.Nutrients · 2026Review
- Article
- Jejunum FABP6 expression and potential mechanism response to Salmonella Pullorum inoculation revealed by proteomic profiling and RT-PCR in Chinese Taihe black-bone silky fowls.Poultry science · 2026Article
- Mechanisms of chronic abdominal pain in inflammatory bowel disease and implications for treatment.Nature reviews. Gastroenterology & hepatology · 2026Review
- Gut-brain communication: types of sensory nerves and mechanisms of activation.Nature reviews. Gastroenterology & hepatology · 2026Review
- Mechanosensitive ion channels in intestinal homeostasis and disease.eGastroenterology · 2026Review
- Neuroimmune Regulation by TRPM2 Channels.Cells · 2026Review
- The vagus nerve as a neurovisceral interface: a comprehensive review.Frontiers in neuroscience · 2026Review
- Microbial dysbiosis alters serotonin signaling in a postinflammatory murine model of visceral pain.American journal of physiology. Gastrointestinal and liver physiology · 2026Article
- Intestinal amino acid metabolic response and its roles in inflammatory bowel disease.Cell communication and signaling : CCS · 2025Review
- A cellular basis for heightened gut sensitivity in females.Science (New York, N.Y.) · 2025Article
- Pro-endometriosis macrophage release of IL-33 is key for endometriosis pain and lesion formation.bioRxiv : the preprint server for biology · 2025Article
- Sensory signals for nausea.Trends in neurosciences · 2025Review
- Epigenomic Profiling Positions ATF7 as a Core Regulator of Colonic Inflammation.Journal of cellular and molecular medicine · 2025Article
- Article
- Population imaging of enterochromaffin cell activity reveals regulation by somatostatin.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Microbiota and enteric nervous system crosstalk in diabetic gastroenteropathy: bridging mechanistic insights to microbiome-based therapies.Frontiers in cellular and infection microbiology · 2025Review
Corrections and comments
- Update of
Authors and funding
14 authors.
Kouki K TouharaDepartment of Physiology, University of California San Franscisco, San Francisco, CA, USA. Koki.Tohara@ucsf.edu.ORCID 0000-0003-3167-9784
Nathan D Rossen *Department of Physiology, University of California San Franscisco, San Francisco, CA, USA.
Fei Deng *State Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, School of Life Sciences, Peking University, Beijing, China.ORCID 0000-0002-1997-4572
Joel Castro *Visceral Pain Research Group, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Andrea M HarringtonVisceral Pain Research Group, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Tifany ChuDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Sonia Garcia-CaraballoVisceral Pain Research Group, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Mariana BrizuelaVisceral Pain Research Group, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Tracey O'DonnellVisceral Pain Research Group, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
Jinhao XuDepartment of Physiology, University of California San Franscisco, San Francisco, CA, USA.ORCID 0000-0003-4018-2825
Onur CilDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-5178-0199
Stuart M BrierleyVisceral Pain Research Group, Hopwood Centre for Neurobiology, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia. Stuart.Brierley@sahmri.com.ORCID 0000-0002-2527-2905
Yulong LiState Key Laboratory of Membrane Biology, New Cornerstone Science Laboratory, School of Life Sciences, Peking University, Beijing, China. yulongli@pku.edu.cn.ORCID 0000-0002-9166-9919
David JuliusDepartment of Physiology, University of California San Franscisco, San Francisco, CA, USA. David.Julius@ucsf.edu.ORCID 0000-0002-6365-4867
Funding
SynthesisP30DK072517 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VERKMAN, ALAN S · 2005 to 2022
$18.1MNatural products as probes of the pain pathwayR35NS105038 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JULIUS, DAVID · 2018 to 2025
$9.0MNovel fluorescent sensors for imaging neuromodulationU01NS113358 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI DAN, YANG, LI, YULONG · 2019 to 2022
$4.3MOptimization of GPCR-based fluorescent sensors for large-scale multiplexed in vivo imaging of neuromodulationU01NS120824 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIRES, SAMUEL ANDREW, LI, YULONG · 2021 to 2024
$3.6MUnderstanding Mechanisms and Sex-Differences in Visceral PainR01DK135714 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOLLY A. INGRAHAM, David Julius · 2023 to 2026
$3.4MMapping gut-spinal cord connections in visceral painU01NS113869 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI INGRAHAM, HOLLY A., JULIUS, DAVID · 2019 to 2021
$2.4MSLC26A3 (DRA) Inhibitors for Treatment of Hyperoxaluria and NephrolithiasisR01DK126070 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CIL, ONUR · 2020 to 2024
$1.6MRoles of CaSR in ocular surface health and diseaseR01EY036139 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Onur Cil · 2024 to 2026
$1.2MWide field-of-view Spinning Disk Confocal with Photoactivation and PhotobleachingS10OD017993 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THORN, KURT · 2015 to 2015
$274kNEI NIH HHS R01 EY036139NIDDK NIH HHS P30 DK072517NIDDK NIH HHS R01 DK126070NIDDK NIH HHS R01 DK135714NIH HHS S10 OD017993NINDS NIH HHS R35 NS105038NINDS NIH HHS U01 NS113358NINDS NIH HHS U01 NS113869NINDS NIH HHS U01 NS120824
Abstract
The crypt-villus structure of the small intestine serves as an essential protective barrier. The integrity of this barrier is monitored by the complex sensory system of the gut, in which serotonergic enterochromaffin (EC) cells play an important part
Indexed as
Enterochromaffin CellsIntestinal MucosaIntestine, SmallStress, PhysiologicalAnimalsFemaleMaleMiceReceptors, Serotonin, 5-HT3Receptors, Serotonin, 5-HT4SerotoninTRPA1 Cation ChannelReceptors, Serotonin, 5-HT3Receptors, Serotonin, 5-HT4SerotoninTRPA1 Cation ChannelTrpa1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.