Evidence map›Paper›PMID 39939774›Full record

ArticleNature2025

Learning produces an orthogonalized state machine in the hippocampus.

Weinan Sun, Johan Winnubst, Maanasa Natrajan, Chongxi Lai, Koichiro Kajikawa, Arco Bast, Michalis Michaelos, Rachel Gattoni, Carsen Stringer, Daniel Flickinger and 2 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Transformations of the spatial activity manifold convey aversive information in CA3.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. The hippocampus as a small-world cognitive map.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Time, space, memory and brain-body rhythms.Nature reviews. Neuroscience · 2026
    Review
  15. Article
  16. Stability through plasticity: Finding robust memories through representational drift.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Weinan Sun *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA. sunw37@gmail.com.ORCID 0000-0002-6723-7964
Johan Winnubst *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Maanasa NatrajanJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-0492-6041
Chongxi LaiJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Koichiro KajikawaJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-8626-4407
Arco BastJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0001-7258-6248
Michalis MichaelosJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Rachel GattoniJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Carsen StringerJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-9229-4100
Daniel FlickingerJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-8361-3122
James E FitzgeraldJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-0949-4188
Nelson SprustonJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA. sprustonn@hhmi.org.ORCID 0000-0003-3118-1636

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

Cognitive maps confer animals with flexible intelligence by representing spatial, temporal and abstract relationships that can be used to shape thought, planning and behaviour. Cognitive maps have been observed in the hippocampus

Indexed as

CA1 Region, HippocampalHippocampusLearningAnimalsCalciumCognitionFemaleMaleMarkov ChainsMiceMice, Inbred C57BLModels, NeurologicalNeural Networks, ComputerNeuronsRewardVirtual RealityCalcium

Identifiers

PMID39939774
PMCPMC11964937

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.