Evidence map›Paper›PMID 39939764›Full record

ArticleNature2025

A crucial role for the cortical amygdala in shaping social encounters.

Antonio V Aubry, Romain Durand-de Cuttoli, Elizabeth Karpman, Rachel L Fisher-Foye, Lyonna F Parise, Flurin Cathomas, C Joseph Burnett, Yewon Yang, Chongzhen Yuan, Alexa R LaBanca and 11 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Traumatic stress recruits an excitatory orbitofrontal-amygdala pathway to drive maladaptive aggression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Sexual Dimorphism in c-Fos Networks Governing Aggression.bioRxiv : the preprint server for biology · 2026
    Article
  9. Science advances · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Antonio V Aubry *Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Romain Durand-de Cuttoli *Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-0240-7608
Elizabeth KarpmanNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Rachel L Fisher-FoyeNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Lyonna F PariseNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-7527-8977
Flurin CathomasNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-8274-1317
C Joseph BurnettNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Yewon YangNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Chongzhen YuanState Key Laboratory of Cognitive Science and Mental Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Alexa R LaBancaNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Kenny L ChanNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-3101-1792
Kion T WinstonNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Hsiao-Yun LinNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Farah DackourNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Arman A TavallaeiNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0009-0000-7390-7525
Johana AlvarezNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Tadaaki NishiokaNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-5080-0407
Hirofumi MorishitaNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-1045-1337
Robert C FroemkeSkirball Institute for Biomolecular Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Long LiState Key Laboratory of Cognitive Science and Mental Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. longli@ibp.ac.cn.ORCID 0000-0002-1354-8468
Scott J RussoNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA. scott.russo@mssm.edu.ORCID 0000-0002-6470-1805

Funding

ResourceP40OD010996 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 2012 to 2024
$11.0M
ROLE OF PERIPHERAL IMMUNE-DERIVED MMP8 IN STRESS SUSCEPTIBILITYR01MH104559 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SCOTT JAMES RUSSO · 2014 to 2026
$9.2M
Maturation of frontal cortico-thalamic circuitry in control of social behaviorR01MH118297 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Hirofumi Morishita · 2019 to 2026
$4.6M
Neural Circuit Mechanisms of Stress-Impaired Social RewardR01MH127820 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RUSSO, SCOTT JAMES · 2021 to 2025
$3.5M
Role of lateral habenula orexin receptor signaling in aggressive social behaviorR01MH114882 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RUSSO, SCOTT JAMES · 2017 to 2021
$2.7M
Rapid and Long-Lasting Antidepressant Action by Targeting Midbrain HCN ChannelsR01MH120637 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RUSSO, SCOTT JAMES · 2019 to 2022
$1.8M
Role of VTA-Amygdala Neural Circuit in Mediating Anxiety-Related BehaviorsR01MH120514 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MOREL, CAROLE S, RUSSO, SCOTT JAMES · 2021 to 2022
$847k
Functions of the Cortical Amygdala in social behaviorK99DA058213 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AUBRY, ANTONIO V · 2023 to 2024
$274k
Brain-gut interactions regulating stress-related gut inflammation and barrier permeabilityK99DK137037 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHAN, KENNY · 2023 to 2024
$182k
NIDA NIH HHS K99 DA058213NIDDK NIH HHS K99 DK137037NIH HHS P40 OD010996NIMH NIH HHS R01 MH104559NIMH NIH HHS R01 MH114882NIMH NIH HHS R01 MH118297NIMH NIH HHS R01 MH120514NIMH NIH HHS R01 MH120637NIMH NIH HHS R01 MH127820
6 · The paper itself

Abstract

Aggression is an evolutionarily conserved behaviour that controls social hierarchies and protects valuable resources. In mice, aggressive behaviour can be broken down into an appetitive phase, which involves approach and investigation, and a consummatory phase, which involves biting, kicking and wrestling

Indexed as

AggressionAmygdalaSocial BehaviorAnimalsFemaleMaleMiceMice, Inbred C57BLNeural PathwaysOptogeneticsProto-Oncogene Proteins c-fosReinforcement, PsychologyRewardProto-Oncogene Proteins c-fos

Identifiers

PMID39939764
PMCPMC11946885

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.