ArticleNature2025
Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
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Who cites it
27 citing papers in PubMed.
- Cancer-associated KBTBD4 mutations induce differentiation defects and confer a unique therapeutic vulnerability.Cancer gene therapy · 2026Article
- High-throughput ligand diversification to discover chemical inducers of proximity.Nature chemical biology · 2026Article
- Structure-Guided Optimization of a Molecular Glue Targeting the KBTBD4-HDAC1/2 Complex.ChemMedChem · 2026Article
- AbioRxiv : the preprint server for biology · 2026Article
- The impactful role of the HDACs in the regulation of gene expression and as targets for disease therapy.Science advances · 2026Review
- Localized heme sensing through a ternary molecular glue.bioRxiv : the preprint server for biology · 2026Article
- The genetic architecture of an allosteric hormone receptor.Nature communications · 2026Article
- Histone deacetylases: Function in tumor development and therapeutic prospects (Review).Oncology letters · 2026Review
- Neo-Cysteine Molecular Glues for Targeting Mutated SMAD4 Protein.Angewandte Chemie (International ed. in English) · 2026Article
- Integrative Structural Modeling of Intrinsically Disordered Regions in a Human HDAC2 Chromatin Remodeling Complex.bioRxiv : the preprint server for biology · 2026Article
- LSD1 Performs Demethylase-Independent and Context-Specific Roles in Ewing Sarcoma.Cancer research communications · 2026Article
- Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry.Nature structural & molecular biology · 2026Article
- Degrons and degradation signals beyond short linear motifs.Nature chemical biology · 2026Review
- Induced proximity-based therapeutic modalities.Nature reviews. Drug discovery · 2026Review
- From Serendipity to Strategy: Rationalizing Molecular Glue Discovery and Proximity-Induced Pharmacology through Chemical Biology.Journal of the American Chemical Society · 2026Review
- MolGlueDB: an online database of molecular glues.Nucleic acids research · 2026Article
- Histopathology and Molecular Pathology of Pineal Region Tumors.Advances and technical standards in neurosurgery · 2026Review
- Clues for glues: from serendipity to nature's blueprints in degrader discovery.Essays in biochemistry · 2025Review
- Versatile roles of inositol hexakisphosphate in the ubiquitin-proteasome system.Essays in biochemistry · 2025Review
- LSD1 Performs Demethylase-Independent and Context-Specific Roles in Ewing Sarcoma.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
- Update of
Authors and funding
23 authors.
Xiaowen Xie *Department of Pharmacology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-9884-1865
Olivia Zhang *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-4299-1485
Megan J R Yeo *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-7906-9080
Ceejay Lee *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-4128-9328
Ran TaoCenter of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.
Stefan A HarryDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
N Connor PayneDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-9513-6194
Eunju NamDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Leena PaulCenter of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-4100-334X
Yiran LiCenter of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-6339-5324
Hui Si KwokDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-2858-8876
Hanjie JiangDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6090-4552
Haibin MaoDepartment of Pharmacology, University of Washington, Seattle, WA, USA.
Jennifer L HadleyCenter of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-1918-747X
Hong LinCenter of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.
Melissa BattsCenter of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0009-0007-3130-6570
Pallavi M GosaviDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-0486-5787
Vincenzo D'AngiolellaEdinburgh Cancer Research, Cancer Research UK Scotland Centre, The Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-8365-9094
Philip A ColeDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6873-7824
Ralph MazitschekBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-1105-689X
Paul A NorthcottCenter of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-1220-5252
Ning ZhengDepartment of Pharmacology, University of Washington, Seattle, WA, USA. nzheng@uw.edu.ORCID 0000-0002-1039-1581
Brian B LiauDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. liau@chemistry.harvard.edu.ORCID 0000-0002-2985-462X
Funding
The DNA Damage Response and Tumorigenesis in the BrainP01CA096832 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI BAKER, SUZANNE J. · 2003 to 2025
$38.0MMapping the Cerebellar Origins of Medulloblastoma SubgroupsR01CA270785 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Paul Northcott · 2023 to 2026
$2.8MMapping Structure-Activity Relationships of Chemical Inhibitors via Genome-EditingDP2GM137494 · NIGMS · HARVARD UNIVERSITY · PI LIAU, BRIAN · 2019 to 2019
$2.5MChemical Genetic Approaches to Study Chromatin ComplexesR01CA274437 · NCI · HARVARD UNIVERSITY · PI Brian Liau · 2023 to 2026
$2.2MChemical Approaches to Understanding Reversible Lysine ModificationsR35GM149229 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI PHILIP A COLE · 2023 to 2026
$1.9MIntegrating Chemical Genetic Approaches with Precision Genome EditingR35GM153476 · NIGMS · HARVARD UNIVERSITY · PI Brian Liau · 2024 to 2026
$1.2MCancer Research UKNCI NIH HHS P01 CA096832NCI NIH HHS R01 CA270785NCI NIH HHS R01 CA274437NIGMS NIH HHS DP2 GM137494NIGMS NIH HHS R35 GM149229NIGMS NIH HHS R35 GM153476
Abstract
Cancer mutations can create neomorphic protein-protein interactions to drive aberrant function
Indexed as
Carrier ProteinsIndolesMedulloblastomaMutationPyrimidinesCell Line, TumorCo-Repressor ProteinsCryoelectron MicroscopyHistone Deacetylase 1Histone Deacetylase 2HumansModels, MolecularProtein MultimerizationProteolysisCarrier ProteinsCo-Repressor ProteinsHDAC1 protein, humanHDAC2 protein, humanHistone Deacetylase 1Histone Deacetylase 2IndolesKBTBD4 protein, humanPyrimidinesUM171 compound
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.