ArticleNature2025
UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
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Who cites it
31 citing papers in PubMed.
- Inter-domain distance analysis reveals conformational changes in the Keap1-Nrf2 stress sensor system.Redox biology · 2026Article
- Cancer-associated KBTBD4 mutations induce differentiation defects and confer a unique therapeutic vulnerability.Cancer gene therapy · 2026Article
- High-throughput ligand diversification to discover chemical inducers of proximity.Nature chemical biology · 2026Article
- Structure-Guided Optimization of a Molecular Glue Targeting the KBTBD4-HDAC1/2 Complex.ChemMedChem · 2026Article
- The synthetic landscape of cereblon (CRBN) binders: from thalidomide to emerging chemotypes.Chemical Society reviews · 2026Review
- Structural determinants for FAT10 activation and transfer from UBA6 to E2 enzymes.Nature communications · 2026Article
- MND1 regulates PANoptosis and stemness of lung adenocarcinoma cells by stabilizing RCOR2 mRNA.Cell death & disease · 2026Article
- Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.Nucleic acids research · 2026Article
- Methods to Study the Molecular Mechanism and Drive the Design of Protein Degraders.Chemical reviews · 2026Review
- Localized heme sensing through a ternary molecular glue.bioRxiv : the preprint server for biology · 2026Article
- Multicomplex Integrative Structural Modeling of a Human Histone Deacetylase Interactome.bioRxiv : the preprint server for biology · 2026Article
- Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry.Nature structural & molecular biology · 2026Article
- Degrons and degradation signals beyond short linear motifs.Nature chemical biology · 2026Review
- Induced proximity-based therapeutic modalities.Nature reviews. Drug discovery · 2026Review
- ZOMES: expanding roles of the PCI complexes from protein metabolism to drug discovery.npj metabolic health and disease · 2026Article
- From Serendipity to Strategy: Rationalizing Molecular Glue Discovery and Proximity-Induced Pharmacology through Chemical Biology.Journal of the American Chemical Society · 2026Review
- MolGlueDB: an online database of molecular glues.Nucleic acids research · 2026Article
- Clues for glues: from serendipity to nature's blueprints in degrader discovery.Essays in biochemistry · 2025Review
- Versatile roles of inositol hexakisphosphate in the ubiquitin-proteasome system.Essays in biochemistry · 2025Review
- Culturing Potential: advances in ex vivo cell culture systems for haematopoietic cell-based regenerative therapies.Regenerative therapy · 2025Review
Corrections and comments
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Authors and funding
29 authors.
Megan J R Yeo *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-7906-9080
Olivia Zhang *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-4299-1485
Xiaowen Xie *Department of Pharmacology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-9884-1865
Eunju Nam *Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
N Connor PayneDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-9513-6194
Pallavi M GosaviDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-0486-5787
Hui Si KwokDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-2858-8876
Irtiza IramDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0009-0009-4037-5054
Ceejay LeeDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-4128-9328
Jiaming LiDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Nicholas J ChenDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-7975-2787
Khanh NguyenBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Hanjie JiangDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6090-4552
Zhipeng A WangDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5693-7359
Kwangwoon LeeDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2021-5186
Haibin MaoDepartment of Pharmacology, University of Washington, Seattle, WA, USA.
Stefan A HarryDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Idris A BarakatDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Mariko TakahashiKrantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Amanda L WaterburyDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-4473-2866
Marco BaroneDepartment of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy.ORCID 0000-0001-7184-2940
Andrea MatteviDepartment of Biology and Biotechnology Lazzaro Spallanzani, University of Pavia, Pavia, Italy.ORCID 0000-0002-9523-7128
Steven A CarrBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-7203-4299
Namrata D UdeshiBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-5312-1402
Liron Bar-PeledKrantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-2687-9546
Philip A ColeDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6873-7824
Ralph MazitschekBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-1105-689X
Brian B LiauDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. liau@chemistry.harvard.edu.ORCID 0000-0002-2985-462X
Ning ZhengDepartment of Pharmacology, University of Washington, Seattle, WA, USA. nzheng@uw.edu.ORCID 0000-0002-1039-1581
Funding
ProteomicsP01CA206978 · NCI · DANA-FARBER CANCER INST · PI GETZ, GAD A · 2016 to 2025
$17.0MCenter of Excellence for High Throughput Proteogenomic CharacterizationU24CA270823 · NCI · BROAD INSTITUTE, INC. · PI STEVEN A CARR, MICHAEL A GILLETTE · 2022 to 2026
$5.3MProteogenomic Predictors of Recurrence in Non-small Cell Lung CancerU01CA271402 · NCI · WASHINGTON UNIVERSITY · PI STEVEN A CARR, MICHAEL A GILLETTE · 2022 to 2026
$5.0MMapping Structure-Activity Relationships of Chemical Inhibitors via Genome-EditingDP2GM137494 · NIGMS · HARVARD UNIVERSITY · PI LIAU, BRIAN · 2019 to 2019
$2.5MChemical Genetic Approaches to Study Chromatin ComplexesR01CA274437 · NCI · HARVARD UNIVERSITY · PI Brian Liau · 2023 to 2026
$2.2MChemical Approaches to Understanding Reversible Lysine ModificationsR35GM149229 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI PHILIP A COLE · 2023 to 2026
$1.9MIntegrating Chemical Genetic Approaches with Precision Genome EditingR35GM153476 · NIGMS · HARVARD UNIVERSITY · PI Brian Liau · 2024 to 2026
$1.2MNCI NIH HHS P01 CA206978NCI NIH HHS R01 CA274437NCI NIH HHS U01 CA271402NCI NIH HHS U24 CA270823NIGMS NIH HHS DP2 GM137494NIGMS NIH HHS R35 GM149229NIGMS NIH HHS R35 GM153476
Abstract
UM171 is a potent agonist of ex vivo human haematopoietic stem cell self-renewal
Indexed as
Co-Repressor ProteinsHistone Deacetylase 1Histone Deacetylase 2IndolesProteolysisPyrimidinesUbiquitin-Protein LigasesCarrier ProteinsCatalytic DomainCryoelectron MicroscopyHistone DemethylasesHumansModels, MolecularProtein BindingCarrier ProteinsCo-Repressor ProteinsHDAC1 protein, humanHDAC2 protein, humanHistone Deacetylase 1Histone Deacetylase 2Histone DemethylasesIndolesKBTBD4 protein, humanKDM1A protein, humanPyrimidinesUbiquitin-Protein LigasesUM171 compound
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.