Evidence map›Paper›PMID 39939760›Full record

ArticleNature2025

Balanced plant helper NLR activation by a modified host protein complex.

Shijia Huang, Junli Wang, Ridan Song, Aolin Jia, Yu Xiao, Yue Sun, Lin Wang, Dennis Mahr, Zhongshou Wu, Zhifu Han and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. Article
  3. Identification and characterization ofHorticulture research · 2026
    Article
  4. Article
  5. Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026
    Review
  6. Structure-informed engineering of plant-microbe interactions.The Plant journal : for cell and molecular biology · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Plant NLRs are getting into higher-order architectures.The Plant journal : for cell and molecular biology · 2026
    Review
  12. Article
  13. Article
  14. Subcellular calcium dynamics and organelle perturbations in resistosome-mediated cell death.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  15. Review
  16. Molecular mechanisms of plant NLR activation and signalling.The Plant journal : for cell and molecular biology · 2026
    Review
  17. Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  18. Review
  19. TIR innovations in plant immunity.The New phytologist · 2026
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shijia Huang *Research Center for Industries of the Future and School of Life Sciences, Westlake University, Hangzhou, China.
Junli Wang *Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Cologne, Germany.ORCID 0000-0001-8825-3894
Ridan Song *School of Life Sciences, Tsinghua University, Beijing, China.
Aolin Jia *National Key Laboratory of Wheat and Maize Crop Science, CIMMYT-China Wheat and Maize Joint Research Centre, Agronomy College, Henan Agricultural University, Zhengzhou, China.
Yu XiaoSchool of Life Sciences, Tsinghua University, Beijing, China.ORCID 0000-0003-2518-9594
Yue SunResearch Center for Industries of the Future and School of Life Sciences, Westlake University, Hangzhou, China.ORCID 0000-0001-6116-7435
Lin WangResearch Center for Industries of the Future and School of Life Sciences, Westlake University, Hangzhou, China.
Dennis MahrDepartment of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Cologne, Germany.ORCID 0009-0006-8129-1621
Zhongshou WuMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0001-6687-1675
Zhifu HanResearch Center for Industries of the Future and School of Life Sciences, Westlake University, Hangzhou, China.
Xin LiMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Jane E ParkerDepartment of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Cologne, Germany. parker@mpipz.mpg.de.ORCID 0000-0002-4700-6480
Jijie ChaiResearch Center for Industries of the Future and School of Life Sciences, Westlake University, Hangzhou, China. chaijijie@westlake.edu.cn.ORCID 0000-0001-7591-3873

Funding

German Research Foundation
6 · The paper itself

Abstract

Nucleotide-binding leucine-rich repeat (NLR) receptors play crucial roles in plant immunity by sensing pathogen effectors

Indexed as

ArabidopsisArabidopsis ProteinsDNA-Binding ProteinsNLR ProteinsPlant ImmunityAllosteric RegulationCarboxylic Ester HydrolasesCryoelectron MicroscopyModels, MolecularProtein BindingProtein DomainsArabidopsis ProteinsCarboxylic Ester HydrolasesDNA-Binding ProteinsEDS1 protein, ArabidopsisNLR ProteinsSAG101 protein, Arabidopsis

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.