Evidence map›Paper›PMID 39939737›Full record

ArticleNature2025

Does a cell's gene expression always reflect its function?

M Neşet Özel, Claude Desplan

Abstract readNews
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. High-resolution single-cell analyses reveal evolutionary constraints and evolvability of sexual circuits inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. High-resolution comparative single-cell transcriptomics ofbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

M Neşet Özel
Claude Desplan

Funding

Signaling from photoreceptors to the optic lobesR01EY013012 · NEI · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 1999 to 2024
$9.4M
Stochastic choices in the retina and optic lobesR01EY013010 · NEI · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 1999 to 2025
$9.1M
Neurogenesis of the optic lobesR01EY017916 · NEI · NEW YORK UNIVERSITY · PI Claude Desplan · 2007 to 2026
$8.0M
Gene Regulatory Networks of Synaptic SpecificityR00NS125117 · NINDS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI Mehmet Neset Ozel · 2024 to 2026
$740k
NEI NIH HHS R01 EY013010NEI NIH HHS R01 EY013012NEI NIH HHS R01 EY017916NINDS NIH HHS R00 NS125117
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell biologyNeuroscienceTranscriptomics

Identifiers

PMID39939737
PMCPMC11991742

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.