Evidence map›Paper›PMID 39939707›Full record

ArticleScientific reports2025

The extracytoplasmic sigma factor σ

Yanfei Cai, Huan Tao, Ahmed Gaballa, Hualiang Pi, John D Helmann

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Multifunctional Bioactivity ofCurrent issues in molecular biology · 2026
    Article
  3. Biocontrol efficiency of nativeCurrent research in microbial sciences · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yanfei Cai *College of Natural Resources and Environment, South China Agricultural University, Guangzhou, People's Republic of China.
Huan Tao *College of Natural Resources and Environment, South China Agricultural University, Guangzhou, People's Republic of China.
Ahmed GaballaDepartment of Microbiology, Cornell University, Ithaca, NY, 14853-8101, USA.
Hualiang PiDepartment of Microbial Pathogenesis and Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT, USA. hualiang.pi@yale.edu.
John D HelmannDepartment of Microbiology, Cornell University, Ithaca, NY, 14853-8101, USA. jdh9@cornell.edu.

Funding

Bacillus subtilis Stress ResponsesR35GM122461 · NIGMS · CORNELL UNIVERSITY · PI John D Helmann · 2017 to 2026
$7.6M
The molecular basis of ferrosome organelle biogenesis and its impact on host-microbe interactionsDP2AI184552 · NIAID · YALE UNIVERSITY · PI Hualiang Pi · 2024 to 2026
$1.5M
The role of a Clostridioides difficile P-type ATPase in ferrosome formation and its impact on cellular physiology and pathogenesisR00AI168483 · NIAID · YALE UNIVERSITY · PI PI, HUALIANG · 2023 to 2023
$249k
NIAID NIH HHS DP2 AI184552NIAID NIH HHS R00 AI168483NIGMS NIH HHS R35 GM122461NIH HHS DP2 AI184552NIH HHS R00 AI168483
6 · The paper itself

Abstract

Plant growth promoting rhizobacteria (PGPR) offer an environmentally friendly and sustainable approach to combat pathogens and enhance crop production. The biocontrol activity of PGPR depends on their ability to colonize plant roots and synthesize antimicrobial compounds that inhibit pathogens. However, the regulatory mechanisms underlying these processes remain unclear. In this study, we isolated and characterized Bacillus velezensis 118, a soil isolate that exhibits potent biocontrol activity against Fusarium wilt of banana. Deletion of sigX, encoding an extracytoplasmic function (ECF) sigma factor previously implicated in controlling biofilm architecture in B. subtilis, reduced biocontrol efficacy. The B. velezensis 118 sigX mutant displayed reduced biofilm formation but had only a minor defect in swarming motility and a negligible impact on lipopeptide production. These findings highlight the importance of regulatory processes important for root colonization in the effectiveness of Bacillus spp. as biocontrol agents against phytopathogens.

Indexed as

BacillusBacterial ProteinsBiofilmsSigma FactorBiological Control AgentsFusariumMusaPlant DiseasesPlant RootsSoil MicrobiologyBacterial ProteinsBiological Control AgentsSigma Factor

Identifiers

PMID39939707
PMCPMC11822112

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.