ArticleScientific reports2025
Connectomic analysis of taste circuits in Drosophila.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Article
- Article
- Cellular source and circuit context organize functional specificity in thebioRxiv : the preprint server for biology · 2026Article
- Article
- Natural noncodingScience advances · 2026Article
- A pair of interneurons that confer positive real-time valence to sweet sensation in Drosophila.Current biology : CB · 2026Article
- Article
- Reconstructing the human brain's wiring diagram from axons up.Trends in neurosciences · 2026Review
- Connectomic mapping of pharyngeal and gut sensory circuits in adultbioRxiv : the preprint server for biology · 2025Article
- From perception to valence: a pair of interneurons that assign positive valence to sweet sensation inbioRxiv : the preprint server for biology · 2025Article
- The Oviposition Inhibitory Neuron is a Potential Hub of Multi-Circuit Integration in theeNeuro · 2025Article
- Artificial sweeteners differentially activate sweet and bitter gustatory neurons in Drosophila.Scientific reports · 2025Article
- Amino acids activate parallel chemosensory pathways in Drosophila.Chemical senses · 2025Article
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Abstract
Our sense of taste is critical for regulating food consumption. The fruit fly Drosophila represents a highly tractable model to investigate mechanisms of taste processing, but taste circuits beyond sensory neurons are largely unidentified. Here, we use a whole-brain connectome to investigate the organization of Drosophila taste circuits. We trace pathways from four populations of sensory neurons that detect different taste modalities and project to the subesophageal zone (SEZ), the primary taste region of the fly brain. We find that second-order taste neurons are primarily located within the SEZ and largely segregated by taste modality, whereas third-order neurons have more projections outside the SEZ and more overlap between modalities. Taste projections out of the SEZ innervate regions implicated in feeding, olfactory processing, and learning. We analyze interconnections within and between taste pathways, characterize modality-dependent differences in taste neuron properties, identify other types of inputs onto taste pathways, and use computational simulations to relate neuronal connectivity to predicted activity. These studies provide insight into the architecture of Drosophila taste circuits.
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