Evidence map›Paper›PMID 39939628›Full record

ArticleScientific reports2025

Accuracy of capillary blood sampling for diagnosing syphilis infection.

Aniúsca Vieira Dos Santos, Ana Carolina Monteiro da Rocha, Giovana Tavares Dos Santos, Igor Araujo Vieira, Cáren Nunes de Oliveira, Suelen Basgalupp, Luana Giongo Pedrotti, Vinicius Serafini Roglio, Emerson Silveira de Brito, Thayane Martins Dornelles and 3 more

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Aniúsca Vieira Dos SantosHospital Moinhos de Vento, PROADI - SUS, Porto Alegre, Brazil.
Ana Carolina Monteiro da RochaHospital Moinhos de Vento, PROADI - SUS, Porto Alegre, Brazil.
Giovana Tavares Dos SantosHospital Moinhos de Vento, PROADI - SUS, Porto Alegre, Brazil.
Igor Araujo VieiraHospital Moinhos de Vento, PROADI - SUS, Porto Alegre, Brazil.
Cáren Nunes de OliveiraHospital Moinhos de Vento, PROADI - SUS, Porto Alegre, Brazil.
Suelen BasgaluppHospital Moinhos de Vento, PROADI - SUS, Porto Alegre, Brazil.
Luana Giongo PedrottiHospital Moinhos de Vento, PROADI - SUS, Porto Alegre, Brazil.
Vinicius Serafini RoglioHospital Moinhos de Vento, PROADI - SUS, Porto Alegre, Brazil.
Emerson Silveira de BritoHospital Moinhos de Vento, PROADI - SUS, Porto Alegre, Brazil.
Thayane Martins DornellesHospital Moinhos de Vento, PROADI - SUS, Porto Alegre, Brazil.
Gerson Fernando Mendes PereiraDepartment of HIV/AIDS, Viral Hepatitis and Sexually Transmitted Infections (DATHI),, Ministry of Health, Brasília, Brazil.
Flávia Moreno Alves de SouzaDepartment of HIV/AIDS, Viral Hepatitis and Sexually Transmitted Infections (DATHI),, Ministry of Health, Brasília, Brazil.
Eliana Marcia WendlandHospital Moinhos de Vento, PROADI - SUS, Porto Alegre, Brazil. elianawend@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Capillary blood collection presents advantages such as reduced invasiveness over venous serum for syphilis diagnosing. This study aimed to compare diagnostic accuracy between capillary and venous blood samples for syphilis diagnosis. Individuals aged ≥ 18 years were included in a cross-sectional study. Syphilis screening was done using Rapid tests (RT) followed by collection of serum capillary and venous samples for VDRL and TPHA test. Sensitivity, specificity, and Kappa coefficient were calculated. Of 191 participants, 115 RT + and 76 RT-. Diagnostic properties did not significantly differ between capillary and venous samples. Capillary VDRL showed 99% sensitivity and 100% specificity, mirroring TPHA results. Furthermore, there was significant agreement between sample types for both serological tests (p < 0.001). Capillary sampling offers comparable diagnostic accuracy to venous collection, regardless of serum quality. Capillary sampling holds promise, particularly in developing countries and large-scale testing initiatives.

Indexed as

Blood Specimen CollectionSyphilisSyphilis SerodiagnosisAdolescentAdultCapillariesCross-Sectional StudiesFemaleHumansMaleMiddle AgedSensitivity and SpecificityTreponema pallidumYoung AdultBlood specimen collectionsSerologic testsSyphilis

Identifiers

PMID39939628
PMCPMC11821845

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.