Evidence map›Paper›PMID 39939595›Full record

ArticleNature communications2025

Charged substrate treatment enhances T cell mediated cancer immunotherapy.

Jia Song, Yanhui Lu, Lulu Liu, Xiaoyu Han, Yanhong Meng, Boon Chin Heng, Xin Zhang, Qun Cui, Ziqi Liu, Yusi Guo and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jia Song *Department of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, PR China.
Yanhui Lu *Department of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, PR China.
Lulu Liu *Department of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, PR China.
Xiaoyu HanDepartment of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, PR China.
Yanhong MengDepartment of Clinical Laboratory, Peking University School and Hospital of Stomatology, Beijing, PR China.
Boon Chin HengDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, PR China.
Xin ZhangInstitute of Systems Biomedicine, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, PR China.
Qun CuiDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, PR China.
Ziqi LiuDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, PR China.
Yusi GuoDepartment of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, PR China.
Xiaona ZhengDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, PR China.
Fuping YouInstitute of Systems Biomedicine, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, PR China.
Dan LuInstitute of Systems Biomedicine, School of Basic Medical Sciences, NHC Key Laboratory of Medical Immunology, Beijing Key Laboratory of Tumor Systems Biology, Peking University Health Science Center, Beijing, PR China. taotao@bjmu.edu.cn.ORCID http://orcid.org/0000-0002-3000-5094
Xuehui ZhangDepartment of Dental Materials & Dental Medical Devices Testing Center, Peking University School and Hospital of Stomatology, Beijing, PR China. zhangxuehui@bjmu.edu.cn.ORCID http://orcid.org/0000-0003-1016-6488
Xuliang DengDepartment of Geriatric Dentistry, Peking University School and Hospital of Stomatology, Beijing, PR China. kqdengxuliang@bjmu.edu.cn.ORCID http://orcid.org/0000-0003-1838-6274

Funding

China Postdoctoral Science Foundation 2022M720008National Natural Science Foundation of China (National Science Foundation of China) 52273258National Natural Science Foundation of China (National Science Foundation of China) 81991505National Natural Science Foundation of China (National Science Foundation of China) 82022032National Natural Science Foundation of China (National Science Foundation of China) 82301076National Natural Science Foundation of China (National Science Foundation of China) U22A20160Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) L222017
6 · The paper itself

Abstract

Biophysical cues play a crucial role in T cell biology, yet their implications in adoptive T cell therapy (ACT) remain largely unknown. Here, we investigate the effect of electrical stimuli on CD8

Indexed as

CD8-Positive T-LymphocytesImmunotherapy, AdoptiveNeoplasmsAnimalsCell DifferentiationCell Line, TumorEarly Growth Response Protein 1Electric StimulationFemaleHumansImmunotherapyMemory T CellsMiceMice, Inbred C57BLReceptors, Antigen, T-CellSignal TransductionEarly Growth Response Protein 1Receptors, Antigen, T-Cell

Identifiers

PMID39939595
PMCPMC11821856

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.