Evidence map›Paper›PMID 39939545›Full record

SynthesisHeart failure reviews2025

Effects of anti-inflammatory therapy in acute heart failure: a systematic review and meta-analysis.

Beth A Davison, Antonio Abbate, Gad Cotter, Domingo Pascual-Figal, Benjamin Van Tassell, Julio Núñez Villota, Lina Atabaeva, Yonathan Freund, Alberto Aimo, Jan Biegus and 35 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Heart failure reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Neuroimmune interactions in cardiovascular homeostasis and disease.American journal of physiology. Cell physiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Beth A DavisonINSERM UMR-S 942 (MASCOT), Université Paris Cité, Paris, France. bethdavison@momentum-research.com.
Antonio AbbateBerne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA.
Gad CotterINSERM UMR-S 942 (MASCOT), Université Paris Cité, Paris, France.
Domingo Pascual-FigalHospital Clínico Universitario Virgen de La Arrixaca, Universidad de Murcia, Murcia, Spain.
Benjamin Van TassellVCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Julio Núñez VillotaCIBER Cardiovascular, Madrid, Spain.
Lina AtabaevaMomentum Research, Inc, 1426 E. NC Highway 54, Suite B, Durham, NC, 27713, USA.
Yonathan FreundSorbonne Université, IMProving Emergency Care FHU, Paris, France.
Alberto AimoFondazione Toscana Gabriele Monasterio, Pisa, Italy.
Jan BiegusInstitute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Michele GolinoVCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Marco Giuseppe Del BuonoVCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Ovidiu ChioncelEmergency Institute for Cardiovascular Diseases "Prof. C.C.Iliescu", University of Medicine Carol Davila, Bucharest, Romania.
Alain Cohen-SolalINSERM UMR-S 942 (MASCOT), Université Paris Cité, Paris, France.
Christopher EdwardsMomentum Research, Inc, 1426 E. NC Highway 54, Suite B, Durham, NC, 27713, USA.
Noelia Fernández-VillaHospital Clínico Universitario Virgen de La Arrixaca, Universidad de Murcia, Murcia, Spain.
Gerasimos FilippatosNational and Kapodistrian University of Athens, Attikon University Hospital, School of Medicine, Athens, Greece.
José Ramón González-JuanateyCIBER Cardiovascular, Madrid, Spain.
Hamlet HayrapetyanErebouni Medical Center, Titogradyan Str, 0087, Yerevan, Armenia.
Borja IbáñezCentro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
Pau Llàcer IborraHospital Universitario Ramón y Cajal, Madrid, Spain.
Francesco MoroniBerne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA.
Jozine M Ter MaatenDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Roshanak MarkleyVCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
Javier González-MartínCIBER Cardiovascular, Madrid, Spain.
Manuel Martínez-SellésHospital Universitario Gregorio Marañón, Madrid, Spain.
Mayranush DrambyanArmenia Medical Center, Margaryan St, 0036, Yerevan, Armenia.
Marco MetraCardiology, ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Sonia MirabetCIBER Cardiovascular, Madrid, Spain.
Andranik Mshetsyan"Mikaelyan" Surgery Institute CJSC, Ezras Hasratyan St., 0093, Yerevan, Armenia.
Maria NovosadovaMomentum Research, Inc, 1426 E. NC Highway 54, Suite B, Durham, NC, 27713, USA.
Matteo PagnesiCardiology, ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Piotr PonikowskiInstitute of Heart Diseases, Wroclaw Medical University, Wroclaw, Poland.
Alejandro Riquelme-PérezHospital Clínico Universitario Virgen de La Arrixaca, Universidad de Murcia, Murcia, Spain.
Malha SadouneINSERM UMR-S 942 (MASCOT), Université Paris Cité, Paris, France.
Manuel Anguita SánchezHospital Universitario Reina Sofía, Cordoba, Spain.
Tabassome SimonSorbonne Université, IMProving Emergency Care FHU, Paris, France.
Mikel Taibo-UrquíaCIBER Cardiovascular, Madrid, Spain.
Koji TakagiMomentum Research, Inc, 1426 E. NC Highway 54, Suite B, Durham, NC, 27713, USA.
Sandra VillarCIBER Cardiovascular, Madrid, Spain.
Chao LiuHeart Failure Center, The First Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, Hebei Province, China.
Adriaan A VoorsDepartment of Cardiology, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Alexandre MebazaaINSERM UMR-S 942 (MASCOT), Université Paris Cité, Paris, France.
Douglas L MannCardiovascular Division, Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, USA.
Antoni Bayés-GenísCIBER Cardiovascular, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We examined current evidence regarding the effects of anti-inflammatory therapies in patients with acute heart failure (AHF) on the risk of cardiovascular outcomes, inflammatory markers, natriuretic peptides, and renal function. Despite growing evidence that inflammation plays a pivotal role in both the development and progression of heart failure, including AHF, only a few trials have been conducted to date in patients with AHF. A systematic literature search of PubMed, Medline, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov was conducted in November 2024 to identify randomized controlled trials (RCTs) evaluating anti-inflammatory therapies in adult patients with AHF. Meta-analyses were conducted to estimate effects on clinical outcomes (death, HF readmission, or worsening HF) and inflammatory and other markers. Five RCTs were identified that enrolled a total of 289 patients to an anti-inflammatory intervention and 273 to a control. Prednisone was examined in two RCTs, anakinra in two, and colchicine in one. Three of the five trials required elevated C-reactive protein (CRP) level for entry. Anti-inflammatory therapy was associated with a reduced risk of the composite outcome (hazard ratio 0.55 [95% CI 0.35-0.86]) and an overall 54% greater reduction in CRP to end of therapy (ratio of geometric mean ratios 0.46 [95% CI 0.29-0.73]), which varied across studies. NT-proBNP and creatinine were not significantly affected. The analysis is limited by the small number of studies but suggests that anti-inflammatory therapy reduces inflammation and may reduce the risk of adverse clinical outcomes in patients with AHF.

Indexed as

Anti-Inflammatory AgentsHeart FailureInflammationAcute DiseaseBiomarkersHumansRandomized Controlled Trials as TopicAnti-Inflammatory AgentsBiomarkersAcute heart failureAnti-inflammatory agentsInflammationPrognosis

Identifiers

PMID39939545

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.