ArticleAnnals of surgical oncology2025
Dynamic Assessment of Local Abdominal Tissue Concentrations of Cisplatin During a HIPEC Procedure: Insights from a Porcine Model.
Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
9 authors.
Funding
Abstract
backgroundThis study aimed to establish a feasible large porcine model for dynamic assessment of cisplatin concentrations in carcinomatosis-relevant abdominal tissues using microdialysis during and after HIPEC combined with cytoreductive surgery.
methodsIn total, eight pigs underwent open abdominal cytoreductive surgery followed by HIPEC. Microdialysis was employed for dynamic cisplatin concentration sampling in abdominal organs and tissue. Cisplatin dialysate concentrations were analyzed using the UPLC-MS/MS method. STATA (version 18.0) was used to perform a two-compartment model with a zero-order distribution to analyze pharmacokinetic parameters.
resultsDetectable cisplatin concentrations in the evaluated target tissues persisted for at least 6 h post-HIPEC. Higher concentrations were found in superficial tissues; however, the difference was not statistically significant. The cisplatin concentrations were comparable for the stomach, rectum, and liver but higher in the peritoneal lining of the abdominal wall, with the lowest median average peak concentration (C
conclusionsOur investigation revealed comparable cisplatin concentrations across abdominal organ surfaces, except higher concentrations in the peritoneal lining of the abdominal wall than in the stomach, rectum, and liver. This model holds promise for future research into HIPEC interventions and anticancer effectiveness.
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