Evidence map›Paper›PMID 39939509›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2025

Quantitative considerations for choosing between Amulet and Watchman FLX and management of device related complications.

Alexander Kushnir, Chirag R Barbhaiya, Lior Jankelson, Douglas Holmes, Anthony Aizer, David Park, Michael Spinelli, Scott Bernstein, Leonard Garber, Felix Yang and 2 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexander KushnirLeon H. Charney Division of Cardiology, Cardiac Electrophysiology, NYU Langone Health, New York University Grossman School of Medicine, 424 East 34th Street, KP 4th Floor, New York, NY, 10016, USA. Alexander.kushnir@nyulangone.org.ORCID http://orcid.org/0000-0003-1644-643X
Chirag R BarbhaiyaLeon H. Charney Division of Cardiology, Cardiac Electrophysiology, NYU Langone Health, New York University Grossman School of Medicine, 424 East 34th Street, KP 4th Floor, New York, NY, 10016, USA.
Lior JankelsonLeon H. Charney Division of Cardiology, Cardiac Electrophysiology, NYU Langone Health, New York University Grossman School of Medicine, 424 East 34th Street, KP 4th Floor, New York, NY, 10016, USA.
Douglas HolmesLeon H. Charney Division of Cardiology, Cardiac Electrophysiology, NYU Langone Health, New York University Grossman School of Medicine, 424 East 34th Street, KP 4th Floor, New York, NY, 10016, USA.
Anthony AizerLeon H. Charney Division of Cardiology, Cardiac Electrophysiology, NYU Langone Health, New York University Grossman School of Medicine, 424 East 34th Street, KP 4th Floor, New York, NY, 10016, USA.
David ParkLeon H. Charney Division of Cardiology, Cardiac Electrophysiology, NYU Langone Health, New York University Grossman School of Medicine, 424 East 34th Street, KP 4th Floor, New York, NY, 10016, USA.
Michael SpinelliLeon H. Charney Division of Cardiology, Cardiac Electrophysiology, NYU Langone Health, New York University Grossman School of Medicine, 424 East 34th Street, KP 4th Floor, New York, NY, 10016, USA.
Scott BernsteinLeon H. Charney Division of Cardiology, Cardiac Electrophysiology, NYU Langone Health, New York University Grossman School of Medicine, 424 East 34th Street, KP 4th Floor, New York, NY, 10016, USA.
Leonard GarberLeon H. Charney Division of Cardiology, Cardiac Electrophysiology, NYU Langone Health, New York University Grossman School of Medicine, 424 East 34th Street, KP 4th Floor, New York, NY, 10016, USA.
Felix YangLeon H. Charney Division of Cardiology, Cardiac Electrophysiology, NYU Langone Health, New York University Grossman School of Medicine, 424 East 34th Street, KP 4th Floor, New York, NY, 10016, USA.
Richard RoLeon H. Charney Division of Cardiology, Cardiac Electrophysiology, NYU Langone Health, New York University Grossman School of Medicine, 424 East 34th Street, KP 4th Floor, New York, NY, 10016, USA.
Larry A ChinitzLeon H. Charney Division of Cardiology, Cardiac Electrophysiology, NYU Langone Health, New York University Grossman School of Medicine, 424 East 34th Street, KP 4th Floor, New York, NY, 10016, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeft atrial appendage occlusion (LAA-O) with Amulet and Watchman FLX are approved for reducing stroke risk in patients with atrial fibrillation when oral anticoagulation is not tolerated. Real world clinical outcomes reported along with imaging data are needed to help clinicians choose between these two technologies and manage device-related complications.

methodsThe study retrospectively analyzed clinical, transesophageal (TEE), and available computed tomography (CT) data from 364 FLX and 292 Amulet procedures performed at an academic medical center over a 4-year period.

resultsLAA-O procedures were successful in 96.7% FLX and 97.3% Amulet cases. FLX implant success rate increased to 98.9% when only patients with LAA diameter to depth ratio < 1.8 and LAA area < 4.4 cm

conclusionsBased on retrospective analysis, an initial strategy with Watchman FLX in patients with favorable LAA anatomy would reduce the risk of late pericardial effusions at the expense of a higher rate of clinically relevant PDL compared to Amulet. Combined AF ablation and LAA-O procedures exhibit less PDL.

Indexed as

Atrial AppendageAtrial FibrillationSeptal Occluder DeviceStrokeAgedEchocardiography, TransesophagealFemaleHumansMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesTomography, X-Ray ComputedTreatment OutcomeAtrial fibrillationLeft atrial appendage occlusion

Identifiers

PMID39939509

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.