ArticleArchives of gynecology and obstetrics2025
The effect of endometrial PRP on fertility outcomes in women with implantation failure or thin endometrium.
Article in Archives of gynecology and obstetrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Value of Platelet-Rich Plasma Treatment in Reproductive Disorders: An Umbrella Review.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Pooled it
- Recipient age and reproductive outcomes in donor oocyte cycles: exploring the potential contribution of uterine aging.Journal of assisted reproduction and genetics · 2026Article
- Subendometrial platelet-rich plasma injection for refractory thin endometrium: a prospective pilot study.Scientific reports · 2026Article
- Platelet-Rich Plasma in Reproductive Endocrinology: Mechanisms and Clinical Applications for Ovarian Reserve, PCOS, and Endometrial Receptivity.Biomedicines · 2025Review
- Platelet-rich plasma therapy for thin endometrium: a comprehensive review.Archives of gynecology and obstetrics · 2025Review
- Comprehensive single-cell transcriptome analysis of autologous platelet-rich plasma therapy on human thin endometrium.Scientific reports · 2025Article
- Impact of Intrauterine Infusion of Autologous Platelet-Rich Plasma on Assisted Reproductive Outcomes in Patients With Recurrent Implantation Failure: A Meta-Analysis of Randomized Controlled Trials.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effect of intrauterine platelet-rich plasma (PRP) treatment on frozen-thawed embryo transfer (FET) cycles in patients with recurrent implantation failure. MATERIALS AND
methodsThe study group consisted of 150 patients. The patients were grouped only as those with thin endometria, those with recurrent implantation failure (RIF), and those with both thin endometria and RIF. All participants underwent frozen embryo transfer. The control group consisted of a total of 150 patients who had normal endometrial thickness and did not have a history of RIF and who presented to the clinic due to unexplained infertility. The rates of biochemical pregnancy, clinical pregnancy, miscarriage and live birth were compared among the groups in terms of fertility outcomes.
resultsIn 150 patients with a thin endometrium or a history of RIF who underwent PRP, the endometrial thickness was significantly greater than the pre-PRP endometrial thickness, and this value was found to be statistically significant (7.38 mm vs. 7.96 mm, p < 0.001). In the thin endometrium group, there was also a statistically significant difference between the endometrial thickness measured before and after PRP (5.85 mm vs 6.65 mm, p < 0.001). The rate of not achieving pregnancy in the RIF group without PRP was found to be significantly greater than that in the control group (53.1% vs 28.7%, p < 0.05). There was no significant difference in pregnancy rates between the PRP groups. Morever, no statistically significant relationship was found between pregnancy status and whether or not PRP was performed in RIF patients (p value > 0.05). Overall, although there was an increase in clinical pregnancy and live birth rates in the PRP group compared with the control group, this difference did not reach statistical significance.
conclusionIn patients suffering from a thin endometrium or RIF, although endometrial PRP increases endometrial thickness, it does not significantly improve fertility outcomes.
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