ArticlePediatric nephrology (Berlin, Germany)2025
Metabolic acidosis is associated with infection severity in pediatric pyelonephritis and pneumonia.
Article in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPyelonephritis is the most common serious bacterial infection in pediatric patients. Several electrolyte abnormalities have been described with pyelonephritis, including metabolic acidosis. We sought to describe the frequency and clinical significance of metabolic acidosis in pediatric patients with acute Escherichia coli (E. coli) pyelonephritis, with comparison to parallel infection group of bacterial pneumonia.
methodsThis was a single-center, retrospective study of pediatric patients with pyelonephritis or pneumonia hospitalization. Nadir serum bicarbonate and anion gap values were collected, and baseline and recovery values when available. Serum electrolyte and creatinine values and markers of infection severity were recorded.
resultsNinety-four pyelonephritis and 95 pneumonia subjects were included. Pyelonephritis mean nadir bicarbonate was 20 (SD 3) mEq/L, statistically significantly lower than 21 (3) mEq/L in pneumonia. Corresponding anion gap was 16 (4) mEq/L in pyelonephritis, statistically significantly lower than 17 (3) mEq/L in pneumonia. There was significant correlation between acidosis and number of fever days in pyelonephritis and between acidosis and hospital length of stay in both groups.
conclusionsThis study demonstrated development of acidosis in 84% of patients with pyelonephritis and in 66% with pneumonia. The mechanism of acidosis appears to have a greater contribution from elevated anion gap in the pneumonia group compared to the pyelonephritis group. Lower nadir serum bicarbonate values are associated with longer hospital length of stay in both groups and greater number of fever days in the pyelonephritis patients.
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