ArticleEuropean radiology2025
MRI of pediatric ovarian masses: validation of the O-RADS framework.
Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Performance of MRI protocols for diagnosis of benign and malignant ovarian tumors: a systematic review and meta-analysis.Abdominal radiology (New York) · 2026Pooled it
- Diagnostic accuracy of a modified non-contrast O-RADS MRI scoring system: a retrospective study.Insights into imaging · 2026Article
- Performance of International Ovarian Tumor Analysis Simple Rules and Ovarian-Adnexal Reporting and Data System for classifying benign and malignant pediatric adnexal lesions using ultrasound.Pediatric radiology · 2026Article
- O-RADS for assessment of adnexal lesions: current status, challenges and future directions.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Review
- Clinical Features of Surgically Managed Adnexal Masses in Children and Adolescents at a Tertiary Referral Center.Children (Basel, Switzerland) · 2026Article
- Imaging Evaluation of Ovarian Masses in a Pediatric Population: A Comprehensive Overview.Cancers · 2025Review
- The Evaluation, Diagnosis, and Management of Ovarian Cysts, Masses, and Their Complications in Fetuses, Infants, Children, and Adolescents.Healthcare (Basel, Switzerland) · 2025Review
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6 authors.
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Abstract
objectiveThe purpose of our study was to test the applicability and implications of using the O-RADS system, which is developed and validated on adults, to review MRI of ovarian masses among pediatric patients. MATERIALS AND
methodsWe retrospectively reviewed consecutive MRI examinations from pediatric patients referred to imaging for suspected ovarian lesions, assessing them using the O-RADS framework. Malignancy frequencies among O-RADS classes were reviewed, and we appraised the potential for such approach to split patients into low (O-RADS 1, 2, and 3) and high risk (O-RADS 4 and 5). Multivariate analyses were conducted to review which clinical or imaging variables yielded a significant impact on malignancy, and a simplified reading framework was proposed accordingly.
results109 female patients were included, with a median age of 13 years (IQR 11-15 years), 7 (7%) presenting with malignant lesions. Malignancy proportions were 0% (95% confidence Interval (CI) 0-35%) for the O-RADS 1 class, 0% (95% CI 0 - 5%) for the O-RADS 2 class, 0% (95% CI 0-14%) for the O-RADS 3 class, 50 (95% CI 1 - 99%) for the O-RADS 4 class, and 75% (95% CI 41-93%) for the O-RADS 5 class. The presence of peritoneal thickening or nodules (p < 0.001), lesion composition (p < 0.001), and absence of intralesional fat (p = 0.051) were individual predictors of malignancy, and the simplified reading framework proposed with such variables identified 11 likely malignant cases, detecting all 7 malignant lesions.
conclusionThe O-RADS system may be applied to MRI performed in the pediatric population for ovarian masses, and a simplified reading framework based on O-RADS could also prove useful in such a setting. KEY POINTS: Question The Ovarian-Adnexal Reporting and Data System (O-RADS) provides the risk of malignancy of ovarian masses among adults but has not been validated among pediatric patients. Findings Malignancy frequencies for O-RADS classes 1, 2, 3, and 4 were 0, 0, 50%, and 75%, indicating a good accuracy in lesion discrimination. Clinical relevance The Ovarian-Adnexal Reporting and Data System (O-RADS) can be effectively applied to MRI examinations in pediatric patients, enabling accurate classification of findings, with potential for score simplification in this age group.
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