Evidence map›Paper›PMID 39939395›Full record

ArticleCommunications medicine2025

An axis-specific mitral annuloplasty ring eliminates mitral regurgitation allowing mitral annular motion in an ovine model.

Yuanjia Zhu, Annabel M Imbrie-Moore, Matthew H Park, Tyler E Cork, Shin Yajima, Robert J Wilkerson, Nicholas A Tran, Mateo Marin-Cuartas, Danielle M Mullis, Sam W Baker and 17 more

Abstract read
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In one paragraph

Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Yuanjia ZhuDepartment of Bioengineering, Stanford University, Stanford, CA, USA.
Annabel M Imbrie-MooreDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Matthew H ParkDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Tyler E CorkDepartment of Bioengineering, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5759-5322
Shin YajimaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Robert J WilkersonDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Nicholas A TranDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Mateo Marin-CuartasDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1000-4710
Danielle M MullisDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Sam W BakerDepartment of Comparative Medicine, Stanford University, Stanford, CA, USA.
Yuko TadaStanford Cardiovascular Institute and Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1410-9894
Tsuyoshi UeyamaStanford Cardiovascular Institute and Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
Matthew LeipzigDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Vicky Y WangDepartment of Radiology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0895-3132
Sidarth EthirajDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Sarah MadiraDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Shreya AnilkumarDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Sabrina K WalshDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Haley J LucianDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Chris HuynhDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Kimberly MorrisDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Ok S KimDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Jack MulliganDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Hanjay WangDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Yasuhiro ShudoDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA, USA.
Daniel B EnnisDepartment of Radiology, Stanford University, Stanford, CA, USA.
Y Joseph WooDepartment of Bioengineering, Stanford University, Stanford, CA, USA. joswoo@stanford.edu.ORCID http://orcid.org/0000-0002-2506-492X

Funding

ANGIOGENIC TISSUE ENGINEERING TO LIMIT POST-INFARCTION VENTRICULAR REMODELINGR01HL089315 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WOO, Y JOSEPH · 2008 to 2023
$6.4M
Biomechanical Optimization of Mitral Valve Repair OperationsR01HL152155 · NHLBI · STANFORD UNIVERSITY · PI WOO, Y JOSEPH · 2020 to 2025
$5.9M
Biomechanical Optimization of Mitral Valve Repair Operations and Annuloplasty Rings for Primary Mitral Valve RegurgitationF32HL158151 · NHLBI · STANFORD UNIVERSITY · PI ZHU, YUANJIA · 2021 to 2022
$144k
National Science Foundation (NSF) Graduate research fellowshipNHLBI NIH HHS F32 HL158151NHLBI NIH HHS R01 HL089315NHLBI NIH HHS R01 HL152155SU | Department of Mechanical Engineering, Stanford University (ME Stanford) DGE-1656518Thoracic Surgery Foundation (TSF) Resident Research Fellowship
6 · The paper itself

Abstract

introductionCurrent mitral annuloplasty rings fail to restrict the anteroposterior distance while allowing dynamic mitral annular changes. We designed and manufactured a mitral annuloplasty ring that demonstrated axis-specific, selective flexibility to meet this clinical need. The objectives were to evaluate ex vivo biomechanics of this ring and to validate the annular dynamics and safety after ring implantation in vivo.

methodsHealthy human mitral annuli (n = 3) were tracked, and motions were isolated. Using the imaging data, we designed and manufactured our axis-specific mitral annuloplasty ring. An ex vivo annular dilation model was used to compare hemodynamics and chordal forces after repair using the axis-specific, rigid, and flexible rings in five porcine mitral valves. In vivo, axis-specific (n = 6), rigid (n = 6), or flexible rings (n = 6) were implanted into male Dorset sheep for annular motion analyses. Five additional animals receiving axis-specific rings survived for up to 6 months.

resultsHere we show the axis-specific, rigid, and flexible rings reduced regurgitation fraction to 4.7 ± 2.7%, 2.4 ± 3.2%, and 17.8 ± 10.0%, respectively. The axis-specific ring demonstrated lower average forces compared to the rigid ring (p = 0.046). Five animals receiving axis-specific rings survived for up to 6 months, with mitral annular motion preserved in vivo. Mature neoendocardial tissue coverage over the device was found to be complete with full endothelialization in all animals.

conclusionsThe axis-specific mitral annuloplasty ring we designed demonstrates excellent capability to repair mitral regurgitation while facilitating dynamic mitral annular motion. This ring has tremendous potential for clinical translatability, representing a promising surgical solution for mitral regurgitation.

Identifiers

PMID39939395
PMCPMC11822063

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.