Evidence map›Paper›PMID 39939342›Full record

ArticleNature communications2025

The systemic lupus erythematosus-associated NCF1

Yanpeng Li, Ana Coelho, Zhilei Li, Malin Alsved, Qixing Li, Rui Xu, Huqiao Luo, Dongxia Liang, Jing Xu, Kutty Selva Nandakumar and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yanpeng LiMedical Inflammation Research, Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-3748-4390
Ana CoelhoMedical Inflammation Research, Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7783-9750
Zhilei LiClinical Pharmacy Division, Department of Pharmacy, Southern University of Science and Technology Hospital, Shenzhen, China.ORCID http://orcid.org/0000-0003-3439-0986
Malin AlsvedDivision of Ergonomics and Aerosol Technology, Faculty of Engineering, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0002-8407-8758
Qixing LiSMU-KI United Medical Inflammation Center, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.ORCID http://orcid.org/0000-0003-4115-7904
Rui XuSMU-KI United Medical Inflammation Center, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.ORCID http://orcid.org/0009-0007-5575-8985
Huqiao LuoMedical Inflammation Research, Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
Dongxia LiangNational and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, Second Affiliated Hospital of Xi' an Jiaotong University (Xibei Hospital), Xi' an, China.ORCID http://orcid.org/0009-0003-2221-9150
Jing XuKey Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, China.
Kutty Selva NandakumarSMU-KI United Medical Inflammation Center, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.ORCID http://orcid.org/0000-0001-7790-8197
Liesu MengNational and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, Second Affiliated Hospital of Xi' an Jiaotong University (Xibei Hospital), Xi' an, China.ORCID http://orcid.org/0000-0003-1985-050X
Jakob LöndahlDivision of Ergonomics and Aerosol Technology, Faculty of Engineering, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0001-9379-592X
Rikard HolmdahlMedical Inflammation Research, Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden. rikard.holmdahl@ki.se.ORCID http://orcid.org/0000-0002-4969-2576

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studying how single nucleotide polymorphisms (SNPs) crosstalk with non-autologous factors to cause complex autoimmune diseases is challenging. An amino acid replacement in the neutrophil cytosolic factor 1 (NCF1-339/NCF1

Indexed as

Lupus Erythematosus, SystemicNADPH OxidasesAllelesAnimalsAutoantibodiesDendritic CellsDisease Models, AnimalFemaleGerminal CenterInterferon-alphaMacrophagesMembrane GlycoproteinsMiceMice, Inbred C57BLPolymorphism, Single NucleotideSignal TransductionAutoantibodiesInterferon-alphaMembrane GlycoproteinsNADPH Oxidasesneutrophil cytosolic factor 1STAT1 Transcription FactorTlr7 protein, mouseToll-Like Receptor 7

Identifiers

PMID39939342
PMCPMC11822037

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.