ArticleScientific reports2025
UPLC-qTOF-MS/MS profiling of phenolic compounds in Fagonia arabica L. and evaluation of their cholinesterase inhibition potential through in-vitro and in-silico approaches.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Chemical Profiling ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Article
- Integrated UHPLC-QTOF-MSJournal of computer-aided molecular design · 2026Article
- Uncovering the antiproliferative potential of Lobophytum pauciflorum metabolites through chemoinformatics and in vitro approaches.Scientific reports · 2026Article
- Phytochemicals from Fagonia glutinosa with anti-hemorrhoid, antipyretic, antiarthritic, antimicrobial and antioxidant activities.Inflammopharmacology · 2026Article
- Article
- Liposomal formulation ofRSC advances · 2025Article
- Bioactive Glycosylated Flavonoids Exhibiting LXR Agonist Activity from a Lauraceae Colombian Species.Plants (Basel, Switzerland) · 2025Article
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Abstract
Fagonia arabica L. is a widely used traditional medicinal herb. This study explored the flavonoid and phenolic acid content in the aerial parts of F. arabica, leading to the tentative identification of 42 compounds using Ultra-Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass/Mass Spectrometry and analyzed with the phytochemical-focused RIKEN tandem mass spectral database (ReSpect) for identification based on authentic standards. The total phenolic and flavonoid content was measured in the ethyl acetate and butanol fractions. The flavonoid content in the ethyl acetate fraction was 101 ± 1.43 µg Rutin/mg, compared to 6.48 ± 0.29 µg rutin/mg in the butanol fraction. Similarly, the ethyl acetate fraction contained 199.14 ± 1.58 µg gallic acid/mg, while the butanol fraction had 47.69 ± 0.54 µg gallic acid/mg. Also, the study demonstrated the effectiveness of the different fractions of Fagonia arabica L. in inhibiting the butyrylcholinesterase enzyme, which is a key contributor to the progression of Alzheimer's disease. At a concentration of 0.45 mg/mL, the ethyl acetate fraction showed the highest efficiency, inhibiting butyrylcholinesterase by 50% (IC
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