Evidence map›Paper›PMID 39939102›Full record

ArticleBMJ open respiratory research2025

Effects of

Dermot Linden, Delia Dorrian, Shikha Tandel, Michael McKelvey, Melanie Bailey, John Conlon, David Moore, Sharon Carr, Clifford C Taggart, Judy M Bradley and 3 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05414370 (Effects of Hyperoxia Induced Pulmonary Inflammation and Organ Injury in a Human in Vivo Model), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05414370 naunknown statusnot on this map

Effects of Hyperoxia Induced Pulmonary Inflammation and Organ Injury in a Human in Vivo Model

TypeinterventionalSponsorBelfast Health and Social Care TrustRan2022 to 2024Enrolled53ConditionsOxygen Toxicity, Pulmonary Injury, Acute Lung InjuryArmsLiquid oxygen, medical air
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dermot LindenWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK dlinden02@qub.ac.uk.ORCID http://orcid.org/0000-0003-0552-1115
Delia DorrianWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Shikha TandelWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Michael McKelveyWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Melanie BaileyMater Infirmorum Hospital Health and Social Services Trust, Belfast, UK.
John ConlonWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK.
David MooreMater Infirmorum Hospital Health and Social Services Trust, Belfast, UK.
Sharon CarrNorthern Ireland Clinical Research Facility (NICRF), Queen's University Belfast Wellcome-Wolfson Institute for Experimental Medicine, Belfast, UK.
Clifford C TaggartWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Judy M BradleyNorthern Ireland Clinical Research Facility (NICRF), Queen's University Belfast Wellcome-Wolfson Institute for Experimental Medicine, Belfast, UK.
Joseph KidneyMater Infirmorum Hospital Health and Social Services Trust, Belfast, UK.
Cecilia M OKaneWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK.
Daniel Francis McAuleyWellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Sciences, Queen's University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0002-3283-1947

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLiberal administration of supplemental oxygen (O METHODS AND ANALYSIS: We hypothesise that (1) short-term exposure to hyperoxia will induce mild pulmonary inflammation and cellular injury and that (2) hyperoxia will accentuate pulmonary inflammation and cellular injury in the setting of inhaled lipopolysaccharide challenge. To test our hypotheses, we will conduct a randomised, double-blind, placebo-controlled study of hyperoxia administered via a high-flow nasal O ETHICS AND DISSEMINATION: Dissemination of the research findings will be achieved in the following ways: (1) Our findings will be presented at national and international meetings with open-access abstracts online and (2) in accordance with the open-access policies proposed by the leading research funding bodies we aim to publish the findings in high quality peer-reviewed open-access journals. TRIAL REGISTRATION NUMBER: NCT05414370.

Indexed as

HyperoxiaOxygen Inhalation TherapyPneumoniaAdultBronchoalveolar Lavage FluidDouble-Blind MethodFemaleHumansLipopolysaccharidesMaleOxygenRandomized Controlled Trials as TopicYoung AdultLipopolysaccharidesOxygenARDSInflammationInnate ImmunityOxidative Stress

Identifiers

PMID39939102
PMCPMC11822437

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.