Evidence map›Paper›PMID 39939074›Full record

ReviewInternational review of cell and molecular biology2025

Circulating biomarkers for diagnosis and response to therapies in cancer patients.

Natália Marcéli Stefanes, Maria Eduarda Cunha-Silva, Lisandra de Oliveira Silva, Laura Otto Walter, Maria Cláudia Santos-Silva, Manas Ranjan Gartia

Abstract readReview
In one paragraph

Review in International review of cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natália Marcéli StefanesDepartment of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA, United States.
Maria Eduarda Cunha-SilvaPost-Graduation Program in Pharmacy, Health Science Center, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Lisandra de Oliveira SilvaPost-Graduation Program in Pharmacy, Health Science Center, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Laura Otto WalterPost-Graduation Program in Pharmacy, Health Science Center, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Maria Cláudia Santos-SilvaPost-Graduation Program in Pharmacy, Health Science Center, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Manas Ranjan GartiaDepartment of Mechanical and Industrial Engineering, Louisiana State University, Baton Rouge, LA, United States. Electronic address: mgartia@lsu.edu.

Funding

Spatial metabolomics with subcellular resolution to identify therapeutic targetsR35GM150564 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI Manas Ranjan Gartia · 2023 to 2026
$1.5M
NIGMS NIH HHS R35 GM150564
6 · The paper itself

Abstract

Cancer presents a significant challenge to global health, driving worldwide concerted efforts to advance early detection, predict therapeutic response, and identify novel targeted therapies. Liquid biopsies emerge as promising avenues for discerning cancer biomarkers, offering less invasive approaches compared to conventional methods. Utilizing increasingly robust technologies, diverse bodily fluids can unveil genetic variants, epigenetic modifications, transcriptional alterations, and metabolomic signatures associated with cancer, thereby furnishing valuable insights for clinical management. This chapter intends to review the sources of cancer-related biomarkers found in circulation, prevalent techniques utilized for their identification, and the potential implications of different biomarker types on the management of cancer. Certain biomarkers currently used in clinical practice will be addressed, as well as potential biomarkers still in the study phase, and the inherent challenges in their practical implementation.

Indexed as

Biomarkers, TumorNeoplasmsAnimalsHumansTreatment OutcomeBiomarkers, TumorBiomarkersCancerCTCCtDNADiagnosticsLiquid biopsy

Identifiers

PMID39939074
PMCPMC11969414

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.